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Table 2 Odds ratio (OR) estimates for Hirschsprung’s Disease from logistic regression models, crude and adjusted OR with 95% confidence interval (CI) for occurrence of Hirschsprung’s Disease based on all live births in the period of 1 january 1996 until 12 March 2016

From: Maternal use of selective serotonin reuptake inhibitors during pregnancy is associated with Hirschsprung’s disease in newborns – a nationwide cohort study

 

SSRI prescriptions redeemed a minimum of one time

No prescriptions for SSRIs

Crude OR (95%CI)

Adjusted ORa (95%CI)

Child born with Hirschsprung’s Disease

16/19.807 (0.08%)

584/1.236.510 (0.05%)

1.71 (1.04–2.81)

1,76 (1.07–2.92)

 

SSRI prescriptions redeemed one time only

No prescriptions for SSRIs

Crude OR (95%CI)

Adjusted ORa (95%CI)

Child born with Hirschsprung’s Disease

7/11.351 (0.06%)

584/1.236.510 (0.05%)

1.31 (0.62–2.75)

1.33 (0.63–2.83)

 

SSRI prescriptions redeemed a minimum of two times

No prescriptions for SSRIs

Crude OR (95%CI)

Adjusted ORa (95%CI)

Child born with Hirschsprung’s Disease

9/8.456 (0.11%)

584/1.236.510 (0.05%)

2.25 (1,17–4.36)

2.34 (1.21–4.55)

  1. aAdjusted for maternal age (≤19, 20–24, 25–29, 30–34, ≥35), maternal smoking (yes/no), sex, of child (male/female), parity (1/<1), calendar year of birth (1996–2001, 2002–2007, 2008–2011, 2012–2016)