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Table 2 Odds ratio (OR) estimates for Hirschsprung’s Disease from logistic regression models, crude and adjusted OR with 95% confidence interval (CI) for occurrence of Hirschsprung’s Disease based on all live births in the period of 1 january 1996 until 12 March 2016

From: Maternal use of selective serotonin reuptake inhibitors during pregnancy is associated with Hirschsprung’s disease in newborns – a nationwide cohort study

  SSRI prescriptions redeemed a minimum of one time No prescriptions for SSRIs Crude OR (95%CI) Adjusted ORa (95%CI)
Child born with Hirschsprung’s Disease 16/19.807 (0.08%) 584/1.236.510 (0.05%) 1.71 (1.04–2.81) 1,76 (1.07–2.92)
  SSRI prescriptions redeemed one time only No prescriptions for SSRIs Crude OR (95%CI) Adjusted ORa (95%CI)
Child born with Hirschsprung’s Disease 7/11.351 (0.06%) 584/1.236.510 (0.05%) 1.31 (0.62–2.75) 1.33 (0.63–2.83)
  SSRI prescriptions redeemed a minimum of two times No prescriptions for SSRIs Crude OR (95%CI) Adjusted ORa (95%CI)
Child born with Hirschsprung’s Disease 9/8.456 (0.11%) 584/1.236.510 (0.05%) 2.25 (1,17–4.36) 2.34 (1.21–4.55)
  1. aAdjusted for maternal age (≤19, 20–24, 25–29, 30–34, ≥35), maternal smoking (yes/no), sex, of child (male/female), parity (1/<1), calendar year of birth (1996–2001, 2002–2007, 2008–2011, 2012–2016)