Skip to main content

Table 1 Characteristics of the exposed and unexposed cohorts. The exposed cohort was divided according to number of redeemed prescriptions of selective serotonin-reuptake inhibitors (SSRI’s): minimum of one prescription, limited to one prescription, and minimum two prescriptions. Total number of children, n = 1.256.317

From: Maternal use of selective serotonin reuptake inhibitors during pregnancy is associated with Hirschsprung’s disease in newborns – a nationwide cohort study

  SSRI prescriptions redeemed a minimum of one time (n = 19,807) SSRI prescriptions redeemed one time only (n = 11.351) SSRI prescriptions redeemed minimum two times (n = 8.456) No prescriptions of SSRIs (n = 1.236.510)
Maternal age
 ≤19 308 (1.6%) 184 (1.6%) 124 (1.5%) 18.039 (1.5%)
 20–24 2.645 (13.4%) 1.530 (13.5%) 1.115 (13.2%) 145.031 (11.7%)
 25–29 5.764 (29.1%) 3.234 (28.5%) 2.530 (29.9%) 415.536 (33.6%)
 30–34 6.678 (33.7%) 3.779 (33.3%) 2.899 (34.3%) 437.740 (35.4%)
 ≥35 4.412 (22.3%) 2.624 (23.1%) 1.788 (21.1%) 220.164 (17.8%)
Maternal smoking status
 No 13.384 (67.6%) 7.838 (69.1%) 5.546 (65.6%) 946.853 (76.6%)
 Yes 5.656 (28.6%) 3.095 (27.3%) 2.561 (30.3%) 186.807 (15.1%)
 Missing 767 (3.9%) 418 (3.7%) 349 (4.1%) 102.850 (8.3%)
Sex of child
 Male 10.249 (51.7%) 5.862 (51.6%) 4.387 (51.9%) 601.949 (48.7%)
 Female 9.558 (48.3%) 5.489 (48.4%) 4.069 (48.1%) 634.561 (51.3%)
Parity
 1 8.792 (44.4%) 4.912 (43.3%) 3.880 (45.9%) 545.646 (44.1%)
 >1 11.015 (55.6%) 6.439 (56.7%) 4.576 (54.1%) 690.864 (55.9%)
Birth year
 1996–2001 1.972 (10.0%) 1.033 (9.1%) 939 (11.1%) 387.716 (31.4%)
 2002–2007 6.077 (30.7%) 2.976 (26.2%) 3.101 (36.7%) 376.939 (30.5%)
 2008–2011 6.787 (34.3%) 3.952 (34.8%) 2.835(33.5%) 240.952 (19.5%)
 2012–2016 4.971 (25.1%) 3.390 (29.9%) 1.581 (18.7%) 230.903 (18.7%)