Table 2 Genetics and active tumours of the patients along the clinical trial
First visit | Last visit (12 months later) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Patient | Age | Gender | Gene VHL locus | Mutation | Left eye | Right eye | ||||
Tumours | Exudation | Tumours | Exudation | Tumours a | Exudation | |||||
1 | 36 | M | Intron 2 | Splice g. 8665, A > G; c.DNA 463,+2A > C | 1 peripheral | - | 1 peripheral | Great exudation | No changes | No exudation |
2 | 33 | F | Intron 2 | Splice.g.8665, A > G; c.DNA 463,+2A > C | 1 juxtapapillary | - | - | - | No changes | - |
3 | 50 | F | Exon 3 | c.501 A > T | 1 juxtapapillary | Exudation | - | - | No changes | Much less exudation |
4 | 20 | M | Exon 3 | c.501 A > T | 1 juxtapapillary | - | - | - | No changes | - |
5 | 15 | M | Ex1–2-3 | del complete VHL | - | - | 1 peripheral | - | No changes | - |
6 | 38 | F | Exon 1 | del exon 1 | 1 juxtapapillary | - | - | - | Withdrawn b | - |
7 | 22 | M | Exon 3 | c.486, C > G | 2 peripheral | - | 2 peripheral | No changes | - | |