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Fig. 7 | Orphanet Journal of Rare Diseases

Fig. 7

From: Transcranial pulsed ultrasound facilitates brain uptake of laronidase in enzyme replacement therapy for Mucopolysaccharidosis type I disease

Fig. 7

Brain EB delivery in B6 mice. a Brain coronal slices of the mouse receiving EB injection only (group 1). There was no significant blue stain region. Left: brain before slicing; 1 and 1’ is the posterior side and anterior side of 1st slice, respectively, and so on. b Brain coronal slices of the one-spot ultrasound treated mouse (group 2). Left: brain before slicing; 1 and 1’ is the posterior side and anterior side of 1st slice, respectively, and so on. c Brain coronal slices of the two-spot ultrasound treated mouse (group 3). Left: brain before slicing; 1 and 1’ is the posterior side and anterior side of 1st slice, respectively, and so on. d Brain EB accumulation in B6 mice. Group 1 (n = 5): B6 mice with EB 100 mg/kg injection. Group 2 (n = 12): B6 mice receiving one-spot ultrasound exposure. MBs 150μL/kg plus EB 100 mg/kg was injected. Group 3 (n = 6): B6 mice receiving two-spot ultrasound exposure. A total dose of MBs 150μL/kg plus EB 100 mg/kg was injected. ** indicates p < 0.01

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