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Fig. 6 | Orphanet Journal of Rare Diseases

Fig. 6

From: Transcranial pulsed ultrasound facilitates brain uptake of laronidase in enzyme replacement therapy for Mucopolysaccharidosis type I disease

Fig. 6

Brain laronidase delivery. Group 1 (n = 3): MPS I mice without any treatment. Group 2 (n = 4): MPS I mice receiving laronidase 2.9 mg/kg injection without ultrasound treatment. Group 3 (n = 4): MPS I mice receiving one-spot ultrasound exposure. MBs 150μL/kg plus laronidase 2.9 mg/kg was injected. Group 4 (n = 4): MPS I mice receiving two-spot ultrasound exposure. A total dose of MBs 150μL/kg plus laronidase 2.9 mg/kg was injected. Group 5 (n = 4): normal B6 mice without any treatment. * indicates p < 0.05 ** indicates p < 0.01

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172