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Table 3 Values obtained before TCZ initiation and after the last infusion for each patient

From: Tocilizumab in the treatment of twelve cases with aa amyloidosis secondary to familial mediterranean fever

Patients

Age (year)

Sex

Comorbid diseases

Disease duration (year)

Amyloidosis duration (year)

Number of applieddoses

Previous biotherapies

Creatinine before treatment (mg/dl)

Creatinine after treatment (mg/dl)

GFR before treatment (ml/min)

GFR after treatment (ml/min)

Proteinuria before treatment (mg/day)

Proteinuria after treatment (mg/day)

CRP before treatment (0–5 mg/L)

CRP after treatment (0–5 mg/L)

Sedimentation before treatment (mm/h)

Sedimentation after treatment (mm/h)

MEFV gene mutation

1

36

M

0

1

1

6

-

3.24

2.4

37.52

45.14

12000

2072

1.5

0.3

32

7

M694V/R761H compound heterozygote

2

44

M

0

27

1

5

Anakinra

2.58

1.86

39.94

59

23677

14962

11.5

2.73

107

43

M694V homozygote

3

45

M

AS

28

0.58

31

Canakinumab

1.28

1.12

86.83

98.72

4725

4462.5

25.5

13.23

32

8

M694Vhomozygote-R202Q homozygote

4

47

F

0

14

0.41

31

-

0.8

0.83

80.84

82.76

2100

1440

14.7

0.31

24

1

M694Vhomozygote-R202Q homozygote

5

23

M

0

15

1

4

-

0.69

0.71

184.9

192.16

3038.5

1392

15.7

14

20

8

 

6

35

M

AS

28

10

28

Infliximab

1.18

1.4

92

81.71

1715.6

2720

13.5

0.72

7

3

M694Vhomozygote-R202Q homozygote

7

41

F

0

17

16

13

Cyclophosphamide

0.72

0.65

116

106.2

3000

1950

9.2

10.14

75

40

M694V homozygote

8

39

F

CROHN DISEASE, AS

7

7

32

Infliximab, Cyclophosphamide, Anakinra, Canakinumab

0.43

0.55

136.6

96

1588

740

9.8

21.5

50

40

M694V homozygote

9

24

F

0

20

3

4

Anakinra

0.4

0.36

166.6

225.89

6018

4707

69.7

3.5

69

61

M694V homozygote

10

22

F

0

8

1

20

-

0.39

0.5

175.02

133

1827

80

40

0.42

89

3

MEFV −/−

11

45

F

AS

8

3

6

Anakinra, Infliximab, Etanercept, Canakinumab

0.8

0.93

80.7

54.3

7061.76

5680

4.4

1.6

56

91

M680Iheterozygote-M694Vheterozygote

12

21

M

0

7

3

4

Anakinra

0.83

0.85

143.6

132.22

11700

16740

1.31

1.42

23

29

M694V/N heterozygote