Patients | Age (year) | Sex | Comorbid diseases | Disease duration (year) | Amyloidosis duration (year) | Number of applieddoses | Previous biotherapies | Creatinine before treatment (mg/dl) | Creatinine after treatment (mg/dl) | GFR before treatment (ml/min) | GFR after treatment (ml/min) | Proteinuria before treatment (mg/day) | Proteinuria after treatment (mg/day) | CRP before treatment (0–5 mg/L) | CRP after treatment (0–5 mg/L) | Sedimentation before treatment (mm/h) | Sedimentation after treatment (mm/h) | MEFV gene mutation |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 36 | M | 0 | 1 | 1 | 6 | - | 3.24 | 2.4 | 37.52 | 45.14 | 12000 | 2072 | 1.5 | 0.3 | 32 | 7 | M694V/R761H compound heterozygote |
2 | 44 | M | 0 | 27 | 1 | 5 | Anakinra | 2.58 | 1.86 | 39.94 | 59 | 23677 | 14962 | 11.5 | 2.73 | 107 | 43 | M694V homozygote |
3 | 45 | M | AS | 28 | 0.58 | 31 | Canakinumab | 1.28 | 1.12 | 86.83 | 98.72 | 4725 | 4462.5 | 25.5 | 13.23 | 32 | 8 | M694Vhomozygote-R202Q homozygote |
4 | 47 | F | 0 | 14 | 0.41 | 31 | - | 0.8 | 0.83 | 80.84 | 82.76 | 2100 | 1440 | 14.7 | 0.31 | 24 | 1 | M694Vhomozygote-R202Q homozygote |
5 | 23 | M | 0 | 15 | 1 | 4 | - | 0.69 | 0.71 | 184.9 | 192.16 | 3038.5 | 1392 | 15.7 | 14 | 20 | 8 | Â |
6 | 35 | M | AS | 28 | 10 | 28 | Infliximab | 1.18 | 1.4 | 92 | 81.71 | 1715.6 | 2720 | 13.5 | 0.72 | 7 | 3 | M694Vhomozygote-R202Q homozygote |
7 | 41 | F | 0 | 17 | 16 | 13 | Cyclophosphamide | 0.72 | 0.65 | 116 | 106.2 | 3000 | 1950 | 9.2 | 10.14 | 75 | 40 | M694V homozygote |
8 | 39 | F | CROHN DISEASE, AS | 7 | 7 | 32 | Infliximab, Cyclophosphamide, Anakinra, Canakinumab | 0.43 | 0.55 | 136.6 | 96 | 1588 | 740 | 9.8 | 21.5 | 50 | 40 | M694V homozygote |
9 | 24 | F | 0 | 20 | 3 | 4 | Anakinra | 0.4 | 0.36 | 166.6 | 225.89 | 6018 | 4707 | 69.7 | 3.5 | 69 | 61 | M694V homozygote |
10 | 22 | F | 0 | 8 | 1 | 20 | - | 0.39 | 0.5 | 175.02 | 133 | 1827 | 80 | 40 | 0.42 | 89 | 3 | MEFV −/− |
11 | 45 | F | AS | 8 | 3 | 6 | Anakinra, Infliximab, Etanercept, Canakinumab | 0.8 | 0.93 | 80.7 | 54.3 | 7061.76 | 5680 | 4.4 | 1.6 | 56 | 91 | M680Iheterozygote-M694Vheterozygote |
12 | 21 | M | 0 | 7 | 3 | 4 | Anakinra | 0.83 | 0.85 | 143.6 | 132.22 | 11700 | 16740 | 1.31 | 1.42 | 23 | 29 | M694V/N heterozygote |