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Table 4 Change in 6MWD

From: The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: an evidence review

Country/countries Name of subgroup First author & publication year Sample size Mean age Mean 6MWD metres 6MWD (sd) Time point for follow up Mean 6MWD metres @FU 6MWD metres @FU (sd)
Australia; Belgium; Canada; France; Germany; Italy; Israel; Spain; Sweden; UK; USA Ambulatory > =5y McDonald, 2013 [22] 57 8.3 361.1 87.5 1y 317.4 152.3
Ambulatory-Steroid treated, <7y 6 NR 382.8 42.7 416.9 35.1
Ambulatory-Steroid treated, > = 7y 34 356.1 93.6 297.1 154.5
Ambulatory-Steroid-naïve, <7y 8 366.3 63.5 341.4 163.9
Italy Ambulatory < =7y, Continuous steroids Mazzone,2014 [74] NR NR NR 18.8 48.2
Ambulatory <350 m(6MWT), <7y Pane, 2014 [34] 9 5.8 307.9 3y −49.3 173
Ambulatory ≥350 m(6MWT), <7y 19 6.16 407.2 19.1 76.8
Ambulatory <350 m(6MWT), ≥7y 25 9.87 288.7 −199.2 121.8
Ambulatory ≥350 m(6MWT), ≥7y 43 8.9 428.7 −115 136.5
Ambulatory-boys 96 NR NR 1y −15.8 77.3
2y −58.9 125.7
3y −104.22 146.2
Mazzone,2014 [74] 106 8.3 1y −25.8 74.3
Mazzone,2014 [46] 113 8.2 −22.7 81
2y −64.7 123.1
Ambulatory boys-None or intermittent steroids Mazzone,2014 [74] 51 NR 1y −40.6 82.2
Ambulatory boys-Continuous steroids 55 −12.1 64.1
Ambulatory boys < =7y 35 −7.8 63.9
Ambulatory boys >7y 71 −42.3 73.9
Ambulatory boys < =7y, None or intermittent steroids NR −0.44 73.7
Ambulatory boys >7y, None or intermittent steroids −66.4 77.7
Ambulatory boys >7y, Continuous steroids −23.6 65.9
Italy; Belgium Ambulatory ≥100 m Pane, 2014 [42] 191 7.9 378.06 74.13 −10.19 69.33
Ambulatory ≥100 m, <7y 80 5.84 383.09 64.4 27.37 53.02
Ambulatory ≥100 m, >7y 111 9.38 374.43 80.5 −37.25 67.21
Ambulatory ≥100 m-Duplications 15 8.6 420.26 85.3 4.37 54.14
Ambulatory ≥100 m-Point mutations 44 7.5 393.62 70.53 −0.84 53.6
Ambulatory ≥100 m-All deletions 132 7.96 368.07 71.93 −14.95 75.09
Ambulatory ≥100 m-Deletions eligible for skipping exon 44 18 8.2 398.16 65.28 −11.78 54.89
Ambulatory ≥100 m-Deletions eligible for skipping exon 45 15 8.4 334.46 72.46 −21.6 111.76
Ambulatory ≥100 m-Deletions eligible for skipping exon 46 7 7.3 335.3 85.47 0.83 24.51
Ambulatory ≥100 m-Deletions eligible for skipping exon 50 9 7.4 358.63 77.11 −7.56 44.84
Ambulatory ≥100 m-Deletions eligible for skipping exon 51 27 7.7 362.66 62.26 −21.59 76.33
Ambulatory ≥100 m-Deletions eligible for skipping exon 53 28 8.6 344.11 67.16 −34.18 77.99
US Ambulatory-boys Henricson, 2012 [75] 17 NR 352 87 −73 135
Henricson, 2013 [21] 24 7.9 369.5 79.3 −53.67 25.96