Table 1 Epidemiological, clinical and laboratory parameters of WD patients mimicking RA
From: Whipple’s disease mimicking rheumatoid arthritis can cause misdiagnosis and treatment failure
patient | WD diagnosis | Musculoskeletal manifestation | Laboratory findings | Extra-articular manifestations | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GI-tract | neurology | cor | skin | ||||||||||||||||||
# | sex | age at first clinical manifestation (years) | time to diagnosis of WD (months) Follow-up after diagnosis (months) | Articular manifestation/number of involved joints/pattern of joint involvement | Radiographic findings | ACR/EULAR Criteria DAS28 (ESR) | CRP (mg/L) ESR (mm) | hemoglobin (♀ 11.6–15.5 g/dl) (♂ 13.5–17.6 g/dl) | SFA (cells/μl) | abdominal pain | weight loss | loss of appetite | nausea | depression | dysgeusia | polyneuropathy | headache | pericarditis | hyperpigmentation | erythema | Immuno-suppressive treatment (treatment duration in months) |
1 | m | 38 | 180 60 | Symmetric polyarthritis (12 large, 40 small): wrists, MCP, PIP, atlanto-axial joint, hips, knees | Erosive arthritis | 7 6.28 | 84.5 22/45 | 7.3 | 500 | X | X | X | X | X | X | Pred (132), SSZ (4), MTX (43), LEF (26), ETN (3), ADA (4), ABA (8), RTX (6), TCZ (3) | |||||
2 | m | 64 | 47 48 | Symmetric polyarthritis (10 large, 2 small): wrists, elbows, hips, knees, ankles | Erosive arthritis | 7 3.58 | 8.2 26/50 | 12.8 | 1100 | X | Pred (35), MTX (5), LEF (1), ADA (4), TCZ (3) | ||||||||||
3 | m | 45 | 56 36 | Asymmetric polyarthritis (1 large, 5 small): MCP joints and left knee | Non erosive arthritis | 5 4.46 | 4.9 27/57 | 11.9 | 7200 | X | - | ||||||||||
4 | m | 34 | 124 56 | Asymmetric polyarthritis (3 large, 3 small): MCP, PIP, left wrist, right knee | Non erosive arthritis | 5 4.34 | 18.3 24/54 | 14.7 | 7800 | X | Pred (6), MTX (4) | ||||||||||
5 | m | 57 | 129 57 | Symmetric arthritis (3 large, 2 small): shoulders, wrists, and left hip | Osteo-proliferation on PIP and MTP, no erosions | 5 4.1 | 37.2 53/89 | 12.5 | No data | X | Pred (4), MTX (8), LEF (7) | ||||||||||
6 | m | 55 | 1 30 | Symmetric arthralgias (2 large, 3 small): MCP, PIP, elbows, vertebral column, sterno-costal joints, axial manifestation | Osteopenia of the hands, no erosions | 4 2.5 | 12 22/45 | 15.1 | No data | Pred (2) | |||||||||||
7 | f | 50 | 42 24 | Asymmetric poly-arthritis (6 large, 4 small): shoulders, wrists, MCPs, knees, and MTPs | Erosive arthritis | 5 4.5 | 106 44/78 | 10.9 | 1300 | X | X | X | X | X | Pred (33), MTX (27), LEF (8), ABA (12) | ||||||