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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: The PPAR pan-agonist bezafibrate ameliorates cardiomyopathy in a mouse model of Barth syndrome

Fig. 2

Bezafibrate (BF) ameliorates systolic function in TazKD mice. a Representative M-mode echocardiographic recordings of 4.5 months old iso-treated TazKD mice fed a diet with or without BF. bd Effects of BF on (b) LV fractional shortening (LV FS), (c) ejection fraction (LV EF) and (d) end-diastolic interventricular wall thicknesses (IVS;d) in 4.5-month-old iso-treated WT (open bars) and TazKD (black bars) mice. e and f LV FS and LV EF indices are shown for 2.5, 4.5 and 7 months old WT (dashed line) and TazKD (solid line) mice. g and h Effects of BF on LV FS and LV EF in 7 months old WT (open bars) and TazKD mice (black bars). Mice were maintained on a diet with or without 0.5% BF during the 2 months between 2.5 and 4.5 months of age (a-d), or 4 months between 3 and 7 months of age (g and h). Numbers in the bars represent the sample size for the corresponding data. Data are presented as means ± standard deviation. Asterisks (*) depict statistical significance (p < 0.05) between groups

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