Table 3 Summary of studies investigating the correlation between MIP and survival
Reference | Therapy Area/Population | Study Type | N | MIP and Survival |
|---|---|---|---|---|
Correlation between MIP and survival | ||||
 Schmidt EP et al., 2006 [37] | ALS | Cohort study | 95 | MIP was an important predictor of 1-year survival (P < 0.05) after controlling for nonpulmonary factors known to predict survival in ALS |
 Baumann F et al., 2010 [38] | ALS | Cohort study | 80 | MIP was significantly associated with survival (P < 0.05); survival time was increased in patients with normal MIP |
 Gay PC et al., 1991 [39] | ALS | Prospective study | 21 | MIP was 100% sensitive for predicting 18-months survival (r = 0.57; P < 0.007) |
 Chaudri MB et al., 2002 [40] | MND (ALS) | Single-center cohort study | 53 | Survivors had a higher percentage of predicted MIP than nonsurvivors (37.83 ± 24.32% vs 20.13 ± 18.43%; P < 0.01) |
 Lopes Almeida JP, et al., 2012 [41] | ALS | Prospective, comparative study | 60 | There was a significant correlation between MIP and 5-years survival (P = 0.02) in patients with ALS using NIV |
 Benzo R et al., 2013 [42] | COPD | Analysis of clinical data from NETT | 1218 | Decrease in MIP > 11 cm H2O was a predictor of 1-year mortality (OR, 2.19; P = 0.0217) |
 Gray-Donald K et al., 1996 [43] | COPD | 3 to 5-years follow-up of a double-blind RCT | 348 | Low MIP was a significant independent predictor of respiratory (HR, 0.64; 95% CI, 0.44–0.95) and all-cause mortality (HR, 0.67; 95% CI, 0.47–0.95) |
 Schols AMWJ et al., 1998 [44] | COPD | RCT | 203 | Improvement in MIP during rehabilitation decreased the risk of death |
 Hodgev VA et al., 2006 [45] | COPD | Prospective cohort study | 63 | A Cox proportional hazards analysis showed that MIP was a significant predictor of mortality (r = 0.91; 95% CI, 0.85–0.97; P = 0.005) |
 Meyer FJ et al., 2001 [47] | Heart failure | Prospective study | 244 | In a univariate Cox regression analysis, MIP was found to be a significant prognostic indicator of survival (P = 0.001) |
 Frankenstein L et al., 2009 [48] | Heart failure | Prospective, observational study | 686 | MIP was identified as a significant predictor of survival by univariate analysis; survivors had a significantly higher MIP and percentage of predicted MIP than nonsurvivors |
 Ionescu AA et al., 1998 [49] | Cystic fibrosis | Single-center study | 49 | Mean % predicted MIP (SD) for survivors was 85.5% (28.4) compared with 64.1% (23.9) for nonsurvivors |
 Marroni CA et al., 2014 [50] | Liver cirrhosis | Prospective cohort study | 86 | Sixty-two percent of patients with MIP < −70 cm H2O survived compared with 93% of patients with MIP > −70 cm H2O (P = 0.0001) |
 Budweiser S et al., 2007 [46] | Chronic hypercapnic respiratory failure | Cohort study | 464 | MIP was a significant predictor of long-term survival; according to stepwise multivariate Cox regression analysis, P0.1/MIP was identified as an independent predictor of survival (P < 0.05) |
 van der Palen J et al., 2004 [51] | Elderly with a mean age of 72.5 years | Cohort study | 3839 | Subjects in the lowest quintile of MIP had a 1.5-fold increased risk of cardiovascular-related death (HR, 1.54; 95% CI, 1.09–2.15) after adjustment for nonpulmonary function covariates |
No correlation between MIP and survival | ||||
 Nizet TAC et al., 2005 [58] | Chronic hypercapnic COPD | Prospective, single-center study | 47 | No significant association |
 Frankenstein L et al., 2008 [54] | CHF | Prospective, single-arm study | 158 | No significant association |
 Habedank D et al., 2013 [55] | CHF | Single-center study | 249 | No significant association |
 Hui D et al., 2014 [56] | Advanced cancer | Prospective, single-center study | 222 | No significant association |
 White AC et al., 2005 [59] | Hematopoietic stem cell transplantation | Prospective observational study | 56 | No significant association |
 Jackson M et al., 1994 [57] | Patients with a thoracoplasty for tuberculosis | Single-center study | 32 | No significant association |