Table 1 Completed RCTs using MIP as a clinical endpoint

Golparvar M et al., 2005 [30]

Primary

Progesterone administration in adult trauma patients during partial support ventilation

40

MIP significantly increased (P < 0.05) 3 h after administration

Gontijo-Amaral C et al., 2012 [26]

Primary

Oral magnesium supplementation in adolescent cystic fibrosis patients

44

Significant increase in MIP between intervention and placebo period (P < 0.001)

Mackersie RC et al., 1991 [31]

Primary

Continuous epidural or continual IV infusions of fentanyl in patients with multiple rib fractures

32

Significant increase in MIP in epidural and fentanyl epidural groups compared with pre-analgesia (P < 0.05)

Sosis M et al., 1987 [32]

Primary

Atracurium treatment in patients requiring intubation

39

Significant decrease in MIP in patients receiving atracurium compared with placebo (P < 0.05)

Andreas S et al., 2006 [35]

Primary

Irbesartan treatment in COPD patients

60

No significant difference in MIP after 4 months of treatment (P = 0.16). Reporting a large standard deviation of MIP.

Skorodin MS et al., 1995 [33]

Primary

Magnesium sulphate administration in COPD patients

72

No significant difference in MIP after 20 and 45 min of treatment (P = NS)

Weisberg J et al., 2002 [34]

Primary

Megestrol acetate administration in COPD patients

128

No significant difference in MIP (P = NS). Reporting a large standard deviation of MIP.

Buyse GM et al., 2013 [36]

Secondary

Idebenone treatment in Duchenne muscular dystrophy patients

21

MIP improved in idebenone group but deteriorated in placebo group (P = NS)