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Table 1 Clinical features of non-optic gliomas in NF1 patients

From: Non-optic glioma in adults and children with neurofibromatosis 1

Patient number Sex Age at first scan with glioma (in years) Symptoms Histology Location Status Treatment
1 M 20.9 Headache PA Grade 1 Frontal Decreased size Surgery
2 F 41.6 No   Temporal Decreased size Chemotherapy (breast cancer)
3 F 48.6 No   Brainstem Stable  
4 F 50.8 No   Temporal No follow up  
5 F 23.4 Seizures   Brainstem Stable  
6 F 10.0 Seizures, headache   Cerebellum Stable  
7 M 31.3 No   Brainstem Stable  
8 M 13.1 No   Frontal Stable  
9ab M 44.6 Ataxia   Cerebellum Stable  
9bb M 44.6 Ataxia   Cerebellum Stable  
9cab M 50.5 Ataxia PA Grade 1 Cerebellum Increased, then decreased size Surgery
10 M 6.5 No PA Grade 1 Brainstem Increased size & enhancement Chemotherapy, biopsy
11ab F 34.9 No   Brainstem No follow up  
12a F 16.4 No PA Grade 1 Corpus Callosum Increased enhancement Incomplete resection before study begin
12ba F 25.3 No   Brainstem Stable  
13 F 38.5 No   Cerebellum Stable  
14 M 17.2 Seizures, headache PA Grade 1 Cerebellum Stable Surgery
15 M 21.3 No PA Grade 1 Corpus Callosum Decreased size & enhancement Surgery
16 M 42.5 No   Temporal Stable  
17 M 42.7 Seizures DNET Cerebellum Stable Incomplete resection before study begin
18a F 14.8 No PA Grade 1 Corpus Callosum No follow up Surgery
18b F 14.8 No   Thalamus No follow up  
19ab F 18.3 No   Brainstem Increased in size  
20 F 16.0 No   Internal capsule Decreased enhancement  
21 F 39.8 No   Cerebellum Stable  
22a F 10.9 No   Cerebellum Decreased enhancement  
22b F 10.9 No   Cerebellum Increased, then decreased in size  
22c F 10.9 No   Cerebellum Stable  
23 M 17.4 No   Brainstem Increased size & enhancement  
24a M 18.1 Double vision, nystagmus PA Grade 1 Brainstem Decreased size Surgery
24b M 18.1 Double vision, nystagmus   Corpus Callosum Increased size  
24c M 18.1 Double vision, nystagmus   Cerebellum Stable  
  1. Abbreviations: PA pilocytic astrocytoma, M male, F female, DNET dysembryoplastic neuroepithelial tumour
  2. adenotes patients with newly-appearing tumours
  3. bdenotes patients with concurrent optic gliomas