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Table 1 Medical history, surgical history, and physical examination findings

From: Early disease progression of Hurler syndrome

Medical and surgical history (n = 55)

Physical examination findings (n = 44)

Medical history

 

Acute or chronic otitis media

89.1%

Joint restrictions

93.2%

Noisy breathing or snoring

85.5%

Corneal clouding

81.8%

Hernia

63.6%

Kyphosis

77.3%

Respiratory infections

54.5%

Hypotonia

61.4%

Swallowing difficulty

45.5%

Hepatomegaly

61.4%

Apnea

32.7%

Transmitted upper respiratory sounds

56.8%

Reflux

30.9%

Nasal congestion

52.3%

Latching or sucking difficulty

21.8%

Protuberant or distended abdomen

45.5%

Diarrhea

18.2%

Nasal drainage

40.9%

Reactive airway disease

16.4%

Muscle weakness

29.5%

Constipation

12.7%

Gingival hypertrophy

22.7%

Laryngomalacia

9.1%

Murmur

22.7%

Surgical history

Abnormal palate

20.5%

Adenoidectomy

72.7%

Sacral dimple

18.2%

Tonsillectomy

61.8%

Mongolian spots

15.9%

Tympanostomy tubes

78.2%

Hirsutism

13.6%

Ventriculoperitoneal shunt

25.5%

Strabismus

9.1%

  1. Information about medical and surgical history was available for all 55 patients. Physical examination findings were available for the subset of patients (n = 44) who were evaluated at our center prior to transplantation