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Table 1 Medical history, surgical history, and physical examination findings

From: Early disease progression of Hurler syndrome

Medical and surgical history (n = 55) Physical examination findings (n = 44)
Medical history  
Acute or chronic otitis media 89.1% Joint restrictions 93.2%
Noisy breathing or snoring 85.5% Corneal clouding 81.8%
Hernia 63.6% Kyphosis 77.3%
Respiratory infections 54.5% Hypotonia 61.4%
Swallowing difficulty 45.5% Hepatomegaly 61.4%
Apnea 32.7% Transmitted upper respiratory sounds 56.8%
Reflux 30.9% Nasal congestion 52.3%
Latching or sucking difficulty 21.8% Protuberant or distended abdomen 45.5%
Diarrhea 18.2% Nasal drainage 40.9%
Reactive airway disease 16.4% Muscle weakness 29.5%
Constipation 12.7% Gingival hypertrophy 22.7%
Laryngomalacia 9.1% Murmur 22.7%
Surgical history Abnormal palate 20.5%
Adenoidectomy 72.7% Sacral dimple 18.2%
Tonsillectomy 61.8% Mongolian spots 15.9%
Tympanostomy tubes 78.2% Hirsutism 13.6%
Ventriculoperitoneal shunt 25.5% Strabismus 9.1%
  1. Information about medical and surgical history was available for all 55 patients. Physical examination findings were available for the subset of patients (n = 44) who were evaluated at our center prior to transplantation