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Fig. 9 | Orphanet Journal of Rare Diseases

Fig. 9

From: Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease

Fig. 9

Defective efferocytosis in chemically-induced Gaucher macrophages. a Representative fluorescence images of CellTracker™ Green-labelled control and apoptotic H460 cells interacting with control and chemically-induced Gaucher macrophages (M). Nuclear morphology was revealed by staining with Hoechst 33342 (1 μg/ml). b Representative images of macrophages during contact and engulfment of apoptotic cells. c Proportion of chemically-induced Gaucher macrophages interacting and engulfing of apoptotic cells treated with CoQ (25 μM) for 72 h. Data represent the mean ± SD of three separate experiments. c p < 0.05 between control and chemically-induced Gaucher macrophages. *p < 0.05 between the presence and the absence of CoQ treatment

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