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Fig. 8 | Orphanet Journal of Rare Diseases

Fig. 8

From: Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease

Fig. 8

Inflammasome activation in chemically-induced Gaucher macrophages. a Western blot analysis of NLRP3, caspase-1 and IL-1β in control and chemically-induced Gaucher macrophages treated with CoQ (25 μM) for 72 h. Cells were supplemented with lipopolysaccharides (LPS) the last 24 h. Alpha-tubulin was used as loading control. b Densitometric analysis of Western blottings. Data represent the mean ± SD of three separate experiments. c p < 0.05 between control and chemically-induced Gaucher macrophages. *p < 0.05 between the presence and the absence of CoQ treatment. c IL-1β levels were determined by ELISA assay as described in Material and Methods. Data represent the mean ± SD of three separate experiments. c p < 0.05 between control and chemically-induced Gaucher macrophages. *p < 0.05 between the presence and the absence of CoQ treatment

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