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Fig. 7 | Orphanet Journal of Rare Diseases

Fig. 7

From: Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease

Fig. 7

Colocalization of autophagosome and mitochondria markers in chemically-induced Gaucher macrophages. a Mitochondria Image analysis of LC3 and cytochrome c immunostaining in control and chemically-induced Gaucher macrophages. Control and chemically-induced Gaucher macrophages were cultured in the presence or absence of CoQ (25 μM) for 72 h. Cells were fixed and immunostained with anti-LC3 (autophagosome marker) and cytochrome c (mitochondrial marker) and examined by fluorescence microscopy. b Quantification of LC3/cytochrome c puncta in control and chemically-induced Gaucher macrophages incubated with or without CoQ (n = 100 cells). Data represent the mean ± SD of three separate experiments. c p < 0.05 between control and chemically-induced Gaucher macrophages. *p < 0.05 between the presence and the absence of CoQ treatment

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