Table 1 Prevalence of autoimmune diseases in SCCH patients and first-degree relatives
Patients | Relatives | Relatives per generation | Denmarka | |||
|---|---|---|---|---|---|---|
Child | Sibling | Parent | ||||
Total N | 70 | 518 | 136 | 256 | 126 | 5 506 574 |
Female sex | 60 (86%) | 272 (52.5%) | 69 (50.7%) | 140 (54.7%) | 63 (50.0%) | 50.5b |
Age (mean ± SD) | 56.3 ± 13.6 | ND | ND | ND | ND | 39.8b |
Autoimmune diseases | ||||||
Psoriasis vulgaris | 10 (14%) | 10 (1.9%) | 4 (2.9%) | 3 (1.2%) | 3 (2.4%) | 0.32% |
Alopecia areata | 0 | 2 (0.4%) | 1 (0.7%) | 1 (0.4%) | 0 | 0.03% |
Rheumatoid arthritis | 2 (3%) | 15 (2.2%) | 1 (0.7%) | 5 (2.0%) | 9 (7.1%) | 0.50% |
Ankylosing spondylitis | 2 (3%) | 1 (0.2%) | 0 | 0 | 0 | 0.07% |
Polymyalgia rheumatica | 1 (1%) | 1 (0.2%) | 0 | 0 | 1 (0.8%) | 0.27% |
Crohn’s disease | 0 | 3 (0.6%) | 1 (0.7%) | 1 (0.4%) | 1 (0.8%) | 0.23% |
Ulcerative colitis | 0 | 4 (0.8%) | 2 (1.5%) | 2 (0.8%) | 0 | 0.48% |
Coeliac disease | 0 | 3 (0.6%) | 0 | 2 (0.8%) | 1 (0.8%) | 0.06% |
Thyrotoxicosis | 1 (1%) | 2 (0.4%) | 1 (0.7%) | 1 (0.4%) | 0 | 0.45% |
Autoimmune thyroiditis | 3 (4%) | 1 (0.2%) | 1 (0.7%) | 0 | 0 | 0.06% |
Diabetes mellitus type 1 | 1 (1%) | 2 (0.4%) | 2 (1.5%) | 0 | 0 | 0.91% |
Multiple sclerosis | 0 | 2 (0.4%) | 1 (0.7%) | 1 (0.4%) | 0 | 0.19% |
Pernicious anemia | 1 (1%) | 3 (0.6%) | 0 | 2 (0.8%) | 1 (0.8%) | 0.05% |
MCD/overlap syndromec | 1 (1%) | 0 | 0 | 0 | 0 | ND |
Scleroderma | 0 | 1 (0.2%) | 0 | 0 | 1 (0.8%) | 0.03% |
Uveitis anterior | 1 (1%) | 0 | 0 | 0 | 0 | 0.21% |
PPP (putative) | 28 (40%) | 9 (1.7%) | 2 (1.5%) | 6 (2.3%) | 1 (0.8%) | ND |
Any autoimmune diseased | 20 (29%) | 47 (9.1%) | 13 (9.6%) | 18 (7.0%) | 16 (12.7%) | 3.9% |
Any AID, including PPPd | 38 (54%) | 56 (10.8%) | 15 (11.0%) | 24 (9.4%) | 17 (13.5%) | ND |
Any AID, excluding psoriasisd | 12 (17%) | 38 (7.3%) | 10 (7.4%) | 15 (5.9%) | 13 (10.3%) | ND |