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Table 1 Prevalence of autoimmune diseases in SCCH patients and first-degree relatives

From: High prevalence of autoimmune disease in the rare inflammatory bone disorder sternocostoclavicular hyperostosis: survey of a Dutch cohort

  Patients Relatives Relatives per generation Denmarka
Child Sibling Parent
Total N 70 518 136 256 126 5 506 574
Female sex 60 (86%) 272 (52.5%) 69 (50.7%) 140 (54.7%) 63 (50.0%) 50.5b
Age (mean ± SD) 56.3 ± 13.6 ND ND ND ND 39.8b
Autoimmune diseases
 Psoriasis vulgaris 10 (14%) 10 (1.9%) 4 (2.9%) 3 (1.2%) 3 (2.4%) 0.32%
 Alopecia areata 0 2 (0.4%) 1 (0.7%) 1 (0.4%) 0 0.03%
 Rheumatoid arthritis 2 (3%) 15 (2.2%) 1 (0.7%) 5 (2.0%) 9 (7.1%) 0.50%
 Ankylosing spondylitis 2 (3%) 1 (0.2%) 0 0 0 0.07%
 Polymyalgia rheumatica 1 (1%) 1 (0.2%) 0 0 1 (0.8%) 0.27%
 Crohn’s disease 0 3 (0.6%) 1 (0.7%) 1 (0.4%) 1 (0.8%) 0.23%
 Ulcerative colitis 0 4 (0.8%) 2 (1.5%) 2 (0.8%) 0 0.48%
 Coeliac disease 0 3 (0.6%) 0 2 (0.8%) 1 (0.8%) 0.06%
 Thyrotoxicosis 1 (1%) 2 (0.4%) 1 (0.7%) 1 (0.4%) 0 0.45%
 Autoimmune thyroiditis 3 (4%) 1 (0.2%) 1 (0.7%) 0 0 0.06%
 Diabetes mellitus type 1 1 (1%) 2 (0.4%) 2 (1.5%) 0 0 0.91%
 Multiple sclerosis 0 2 (0.4%) 1 (0.7%) 1 (0.4%) 0 0.19%
 Pernicious anemia 1 (1%) 3 (0.6%) 0 2 (0.8%) 1 (0.8%) 0.05%
 MCD/overlap syndromec 1 (1%) 0 0 0 0 ND
 Scleroderma 0 1 (0.2%) 0 0 1 (0.8%) 0.03%
 Uveitis anterior 1 (1%) 0 0 0 0 0.21%
 PPP (putative) 28 (40%) 9 (1.7%) 2 (1.5%) 6 (2.3%) 1 (0.8%) ND
Any autoimmune diseased 20 (29%) 47 (9.1%) 13 (9.6%) 18 (7.0%) 16 (12.7%) 3.9%
Any AID, including PPPd 38 (54%) 56 (10.8%) 15 (11.0%) 24 (9.4%) 17 (13.5%) ND
Any AID, excluding psoriasisd 12 (17%) 38 (7.3%) 10 (7.4%) 15 (5.9%) 13 (10.3%) ND
  1. Abbreviations: SD standard deviation, ND no data, PPP palmoplantar pustulosis, MCD mixed connective tissue disease, AID autoimmune disease
  2. aDanish general population prevalence data on 30 autoimmune diseases (from ICD-8 and ICD-10 codes), adapted from Eaton et al. [24]
  3. bDemographic characteristics as of 1 January 2006 adapted from StatBank Denmark (http://statbank.dk/). Sex ratio and mean age respectively were retrieved from the FOLK2 and GALDER datasets
  4. cThis patient was analysed in a separate category; she had concomitant diagnoses of MCD and Sjögren’s syndrome
  5. dReported figures take into account individuals with multiple diagnoses. Four patients and two relatives had two autoimmune diseases