Skip to main content

Table 1 Demographic, clinical, respiratory and sleep variables in patients with congenital central hypoventilation syndrome (CCHS) and healthy controls

From: Normal sleep on mechanical ventilation in adult patients with congenital central alveolar hypoventilation (Ondine’s curse syndrome)

  Patients with CCHS Healthy Controls P value
Number 14 15  
Gender, F/M 9/5 11/4 0.70
Age, y 23.0 (19.0; 24.8) 23.0 (22.0; 26.0) 0.42
Body mass index, kg/m2 21.7 (20.7; 24.0) 21.7 (20.1; 22.8) 0.95
Epworth sleepiness score, 0-24 7 (2; 8) 6 (4; 7) 0.73
NIV/Tracheotomy 10/4 NA NA
Blood gases
 pH 7.42 (7.38; 7.44) NA NA
 PaCO2, mmHg 40 (34; 44) NA NA
 PaO2, mmHg 101 (86: 112) NA NA
 Awake SpO2, % 98 (96; 99) NA NA
 Total sleep period, min 514.5 (489.5; 585.8) 552.0 (522.5; 588.5) 0.47
 Total sleep time, min 484.0 (432.8; 512.3) 500.0 (446.5; 540.0) 0.42
 Sleep efficiency, % 93.7 (82.9; 95.1) 92.9 (88.6; 95.0) 0.86
Latency to, min
 Sleep onset 14.0 (7.0; 20.5) 33.0 (18.0; 49.0) 0.052
 N3 26.3 (24.0; 30.1) 49.5 (34.3; 66.9) 0.005
 REM sleep 64.5 (52.3; 81.5) 64.0 (56.5; 69.0) 0.95
Sleep stages, min
 N1 17.5 (10.5; 25.5) 26.0 (15.5; 32.0) 0.21
 N2 209.5 (187.3; 247.0) 223.0 (190.0; 245.5) 0.65
 N3 117.0 (109.8; 133.8) 120.0 (106.0; 142.0) 0.83
 REM sleep 110.0 (90.3; 122.3) 126.0 (109.0; 133.0) 0.11
Arousals (/h) 13.3 (8.5; 17.4) 11.5 (9.2; 15.2) 0.79
Periodic leg movements (/h) 0.1 (0.0; 3.3) 0.2 (0.0; 0.7) 0.95
  1. NA not available, NIV noninvasive ventilation, Values are median (interquartile range)