Table 3 Urine pharmacokinetic variables of lucerastat
Study | Dose regimen | Ae 0-12h [21] | Ae 12-24h [21] | Ae 0-24h [21] | % of dose | |
|---|---|---|---|---|---|---|
SAD | 100 mg | 47 (21) | 6 (4) | 53 (24) | 53 (24) | |
300 mg | 145 (52) | 10 (6) | 153 (54) | 49 (20) | ||
500 mg | 256 (24) | 24 (12) | 280 (12) | 56 (6) | ||
1000 mg | 452 (122) | 49 (46) | 501 (98) | 50 (10) | ||
2x1000 mg | 524 (50) | 304 (191) | 904 (295) | 45 (15) | ||
MAD | 200 mg | Day 7 | 160 (14) | 145 (31) | 305 (40) | 76 (10) |
500 mg | Day 7 | 357 (64) | 362 (56) | 719 (101) | 72 (10) | |
1000 mg | Day 7 | 864 (243) | 830 (152) | 1695 (289) | 85 (15) |