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Table 3 Multivariate analysis for PCS and MCS of the SF-12v2 and coefficients#1

From: Impacts of caring for a child with the CDKL5 disorder on parental wellbeing and family quality of life

Measure   PCS MCS
  Coefficient (95% CI) Coefficient (95% CI)
Feeding pattern Oral intake only Reference Reference
Combination use −1.01 (−5.63, 3.60) −1.49 (−8.36, 5.37)
Enteral nutrition only −4.51** (−8.12, −0.89) 6.67** (1.29 to 12.05)
Dietary concerns None Reference Reference
Occasional −4.98** (−8.11, −1.86) −0.88 (−5.97, 4.20)
Frequent or constant −1.81 (−5.51, 1.88) 0.30 (−5.72, 6.32)
Floor sitting No assistance Reference Reference
Some assistance 0.21 (−4.01, 4.42) −1.59 (−8.14, 4.96)
Maximal assistance/unable −2.27 (−5.44, 0.90) 1.03 (−3.89, 5.96)
Taking 10 steps forward No assistance Reference Reference
Some assistance 1.20 (−3.52, 5.91) −1.23 (−8.59, 6.14)
Maximal assistance/unable −1.85 (−5.34, 1.64) 0.15 (−5.30, 5.61)
Eye contact No Reference Reference
Yes 1.04 (−1.67, 3.75) 1.77 (−2.46, 6.00)
Communication No/Simple method Reference Reference
Complex gestures/vocalisation 0.45 (−2.58, 3.48) −0.85 (−5.42, 3.72)
Sign/Spoken language 1.03 (−3.00, 5.06) 0.14 (−5.93, 6.21)
Seizure frequency Absent Reference Reference
Yearly/Monthly −0.55 (−6.78, 5.68) −2.82 (−12.11, 6.46)
Weekly 0.42 (−5.41, 6.25) −3.42 (−12.11, 5.27)
1 to 5 times a day −0.76 (−5.88, 4.35) −1.90 (−9.52, 5.73)
At least 5 times a day −0.17 (−6.07, 5.72) 0.09 (−8.69, 8.88)
Sleep difficulties 1.00 to 1.50 (1st quartile) Reference Reference
1.50 to 1.81 (2nd quartile) 0.37 (−3.31, 4.04) −2.58 (−8.11, 2.95)
1.81 to 2.17 (3rd quartile) 2.12 (−1.65, 5.89) −2.57 (−8.25, 3.10)
2.17 to 5.00 (4th quartile) 1.02 (−2.88, 4.93) −8.04** (−13.91, −2.16)
Hospitalisation rate 0 to 0.38 (1st quartile) Reference Reference
0.38 to 0.86 (2nd quartile) −0.60 (−4.49, 3.30) −1.13 (−7.01, 4.73)
0.86 to 2.14 (3rd quartile) −2.27 (−6.42, 1.87) −4.22 (−10.47, 2.03)
2.14 to 13.70 (4th quartile) −1.15 (−5.31, 3.00) −0.88 (−7.15, 5.38)
Respite care None Reference Reference
Formal only 0.08 (−4.63, 4.79) 1.54 (−5.63, 8.69)
Informal only −0.80 (−4.57, 2.97) −1.54 (−7.26, 4.18)
Both formal and informal 1.00 (−2.79, 4.78) −2.73 (−8.48, 3.02)
Financial difficulty No Reference Reference
Yes −1.76 (−4.43, 0.92) −4.75** (−8.78, −0.71)
  1. #1Adjusted for parent’s age (a continuous variable), parent’s qualification (a binary variable; university degree or lower), parent’s work status, number of siblings, the first child, child’s age (a continuous variable) and child’s country of birth (a binary variable; North America or others)
  2. **p <0.05
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172