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Table 2 Clinical and metabolic parameters of C1-INH-HAE patients in relation to the investigated GR polymorphisms

From: Glucocorticoid receptor gene polymorphisms in hereditary angioedema with C1-inhibitor deficiency

  N363S BclI A3669G
  Non-carriers n = 94 Carriers n = 12 Non-carriers n = 51 Heterozygous carriers n = 39 Homozygous carriers n = 16 Non-carriers n = 75 Carriers n = 31
  (54f + 40 m) (5f + 7 m) (31f + 20 m) (20f + 19 m) (8f + 8 m) (40f + 35 m) (19f + 12 m)
Age (mean ± SD) 39.88 ± 18.04 32.54 ± 11.88 35.02 ± 17.84 42.33 ± 15.99 43.79 ± 18.68 39.4 ± 18.2 39.2 ± 15.1
Onset of the initial attack (age) (mean ± SD) 12.23 ± 9.51 8.08 ± 5.68 11.71 ± 11.34 11.18 ± 6.58 13.3 ± 7.9 11.9 ± 8.8 11.2 ± 10.2
Number of attacks /year (mean ± SD) 8.4 ± 11.2 11.9 ± 13.3 10.2 ± 13.6 7.4 ± 9.9 7.5 ± 6.3 8.4 ± 12.4 10 ± 8.9
Average C1-INH consumption (amp/year) (mean ± SD) 1.6 ± 3.5 2.4 ± 3.9 1.8 ± 4.0 1.6 ± 3.1 1.6 ± 3.2 2.2 ± 3.5 1.5 ± 3.6
BMI (kg/m2) (mean ± SD) 24.99 ± 5.55 27.29 ± 3.91 24.17 ± 5.56 25.99 ± 5.21 26.87 ± 5.11 24.2 ± 5.03° 28.4 ± 4.8°
Prevalence of hypertension (%) 18.1 8.33 7.80* 17.95 37.5* 17.3 16.1
Prevalence of diabetes (%) 5.3 0% 3.9 5.13 6.2 5.3 3.2
  1. Clinical and metabolic parameters of C1-INH-HAE patients in relation to the investigated GR polymorphisms. Results are mean ± SD. Statistically significant values are marked by bold typeset. °p < 0.0001 statistical power 98.2%, *p = 0.0126, statistical power 84.6%
  2. Abbreviations: f female, m male.