Table 2 Clinical and metabolic parameters of C1-INH-HAE patients in relation to the investigated GR polymorphisms
From: Glucocorticoid receptor gene polymorphisms in hereditary angioedema with C1-inhibitor deficiency
N363S | BclI | A3669G | |||||
|---|---|---|---|---|---|---|---|
Non-carriers n = 94 | Carriers n = 12 | Non-carriers n = 51 | Heterozygous carriers n = 39 | Homozygous carriers n = 16 | Non-carriers n = 75 | Carriers n = 31 | |
(54f + 40 m) | (5f + 7 m) | (31f + 20 m) | (20f + 19 m) | (8f + 8 m) | (40f + 35 m) | (19f + 12 m) | |
Age (mean ± SD) | 39.88 ± 18.04 | 32.54 ± 11.88 | 35.02 ± 17.84 | 42.33 ± 15.99 | 43.79 ± 18.68 | 39.4 ± 18.2 | 39.2 ± 15.1 |
Onset of the initial attack (age) (mean ± SD) | 12.23 ± 9.51 | 8.08 ± 5.68 | 11.71 ± 11.34 | 11.18 ± 6.58 | 13.3 ± 7.9 | 11.9 ± 8.8 | 11.2 ± 10.2 |
Number of attacks /year (mean ± SD) | 8.4 ± 11.2 | 11.9 ± 13.3 | 10.2 ± 13.6 | 7.4 ± 9.9 | 7.5 ± 6.3 | 8.4 ± 12.4 | 10 ± 8.9 |
Average C1-INH consumption (amp/year) (mean ± SD) | 1.6 ± 3.5 | 2.4 ± 3.9 | 1.8 ± 4.0 | 1.6 ± 3.1 | 1.6 ± 3.2 | 2.2 ± 3.5 | 1.5 ± 3.6 |
BMI (kg/m2) (mean ± SD) | 24.99 ± 5.55 | 27.29 ± 3.91 | 24.17 ± 5.56 | 25.99 ± 5.21 | 26.87 ± 5.11 | 24.2 ± 5.03° | 28.4 ± 4.8° |
Prevalence of hypertension (%) | 18.1 | 8.33 | 7.80* | 17.95 | 37.5* | 17.3 | 16.1 |
Prevalence of diabetes (%) | 5.3 | 0% | 3.9 | 5.13 | 6.2 | 5.3 | 3.2 |