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Table 1 Minor allele frequency and carrier state for GR polymorphisms in C1-INH-HAE patients and in healthy controls

From: Glucocorticoid receptor gene polymorphisms in hereditary angioedema with C1-inhibitor deficiency

Polymorphism C1-INH- HAE Healthy control group p value
N = 139 N = 160
 N363S
  Minor allele frequency 0.05 0.031 0.78
  Heterozygous carriers (+/−) 13 (9.3%) 10 (6.3%) 0.77
  Homozygous carriers (+/+) - - -
  Non-carriers 126 (90.7%) (96,7%) (90.7%) 150 (93.7%) 0.77
 BclI
  Minor allele frequency 0.36 0.35 0.87
  Heterozygous carriers (+/−) 53 (38.1%) 82 (51.3%) 0.08
  Homozygous carriers (+/+) 24 (17.3%) 16 (10%) 0.24
  Non-carriers 62 (44.6%) 62 (38.7%) 0.72
 A3669G
  Minor allele frequency 0.15 0.22 0.11
  Heterozygous carriers (+/−) 39 (28.1%) 48 (30%) 0.99
  Homozygous carriers (+/+) 2 (1.4%) 12 (7.5%) 0.04
  Non-carriers 98 (70.5%) 100 (62.5%) 0.42
  1. Minor allele frequency and carrier state for GR polymorphisms in C1-INH-HAE patients and in healthy controls. The p value was adjusted with Bonferroni correction. Statistically significant values are marked by bold typeset