Table 2 Progressive nature of AGU: mouth, head and face, skin, connective tissue, health and test findings according age
Age in years | Mouth | Head and Face | Skin | Connective tissue | State of health | Test findings, brain MRI |
|---|---|---|---|---|---|---|
<2 | Normal | Macrocephalia, broad mandiple, short and broad nose | Facial erythema | Hernia, planovalgus, clubfoot | Respiratory infections, diarrhoea | Vacuolated cells in all tissues |
2–5 | Large tongue, broad dental arches, food retention | Generous cheeks, periorbital fullnes | Piezogymic papules in heels, white spots | Tapered fingers, lordosis | Respiratory infections, diarrhoea | Delayed myelination, decreased T2 signal intensity of the thalami |
6–9 | Gingivitis, oral candida | No change | No change | Bulging abdomen, knock-knees | Benign subcutaneous tumors | Thick and misshapen ribs, vertebral dysplasia |
10–15 | Gingival overgrowts | No change | Facial seborrhoea | Broad and low ball of foot | Arthritis rheumatoides | Decreased T2 pulvinar signal intensity, mild cerebral atrophy |
16–19 | Edemic cheeks, cross bite | No change | Angiokeratoma | Thoracic deformity | Psychotic periods, epilepsy | Neutropenia, thrombopenia, mild cerebellar atrophy |
20–24 | No change | Coarsening facial feature | Facial angiofibromas | Childish appearance | Restless sleep, confusion periods | Evident cerebral and cerebellar atrophy |
25–34 | No change | Thick eyebrows | Facial rosacea | Poor carriage | Epilepsy | – |
35–44 | Loss of teeth and loss of gingical overgrowts | Thick and broad/full lips | Loose skin | Muscle atrophy and hypotony | Bursitis, osteoporosis, orofacial | Attenuation in EEG |
45+ | Drooling | Microcephalia | Angiofibromas and rosacea increse | Contractures in fingers and elbows | Abscesses, fistula of skin, diarrhoea, anaemia, hearth insufficiency, p | Progression of cerebral and cerebellar atrophy |