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Table 7 Laboratory Abnormalities in A-T

From: Ataxia telangiectasia: a review

• Elevated and slowly increasing serum alpha-fetoprotein levels after two years of age

• Low serum levels of immunoglobulins (IgA, IgG, IgG subclasses, IgE) and lymphopenia (particularly affecting T-lymphocytes)

• Spontaneous and X-ray induced chromosomal breaks and rearrangements in cultured lymphocytes and fibroblasts

• Reduced survival of cultured lymphocytes and fibroblasts after exposure to ionizing radiation [209]

• Cerebellar atrophy detected by MRI

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172