| Classic Form | Mild Form |
---|---|---|
Neurological Manifestations | Neurological deficits are typically observed during the toddler years resulting in wheelchair dependency around the age of 10. | Individuals have more mild neurological deficits in childhood with slower age-related neurodegeneration. The predominant neurological symptoms or symptoms to present first may be myoclonus, dystonia, choreoathetosis or tremor with ataxia appearing later [175–177]. Oculomotor apraxia may also appear later or not at all [95]. |
Immunodeficiencies | Roughly two-thirds of people with classic A-T suffer from some type of immunodeficiency and/or lymphopenia. | Immunodeficiencies do occur, but are less common. |
Pulmonary Disease | Relatively common. | Less common. |
Cancer | Although malignancies in these individuals tend to occur at a younger age and are often lymphoid in nature, cancers in older individuals do occur and include both hematopoietic and non-hematopoietic malignancies. | Malignancies tend to appear later in life and include a higher proportion of non-hematopoietic cancers. The diagnosis of cancer can precede the diagnosis of A-T. |