Table 2 Problems Observed in Aging or Older People with A-T

• Ballistic, retropulsive or jerky movements

• Sensory and motor neuropathy

• Brain telangiectasia (observed by MRI)

• Restrictive lung disease

• Elevated cholesterol and triglyceride levels

• Glucose intolerance and diabetes

• Liver abnormalities (e.g. fatty liver; non-alcoholic cirrhosis; elevated serum transaminases)

• Changes in the types of malignancies (there is an increased incidence for both lymphoid and solid tumors)

• Osteoporosis/osteopenia and low vitamin D levels

• Postural scoliosis and progressive foot deformities

• Gastroesophageal reflux (especially if reflux was an issue in infanthood)

• Early menopause

• Depression

• Aging parents and caregivers