Table 1 Clinical and epidemiological features and treatment response of symmetrical acrokeratoderma
From: Symmetrical acrokeratoderma: a case series in Indian patients
Patient No | Age at onset (Years)/Sex | Total disease duration (Years) | Sites involved | Family history | Seasonal variation and natural course | Associated cutaneous diseases | Follow-up duration (months) | Treatment offered/duration of treatment | Response to treatment |
|---|---|---|---|---|---|---|---|---|---|
1 | 24/M | 6 | Dorsum of hand and feet, wrist, flexural surface of forearm, ankle, shins, knee joint | No | Summer exacerbation. Resolves completely in winter | No | 14 | Topical retinoic acid 0.1% gel and 10% urea | Mild improvement. Relapse in summer |
2 | 11/M | 11 | Knuckles, interphalangeal joint, wrist, elbow | No | Summer exacerbation. Resolves completely in winter | No | 14 | Topical retinoic acid 0.1% gel + 10% urea | No improvement |
Acitretin 10 mg/day* 16 weeks. Topical 10% urea | Cleared completely | ||||||||
3 | 21/M | 7 | Knuckles, wrist, ankle | No | Summer exacerbation. Mild improvement in winter | No | 15 | Acitretin 25mg/day* 12 weeks. Topical 10% urea | Cleared completely. Seasonal recurrence. |
4 | 28/M | 8 | Dorsum of hand and feet Forearm | No | Summer exacerbation. Resolves completely in winter | No | 15 | Acitretin 25mg* 4 weeks. Topical 10% urea | Cleared completely. Seasonal recurrence. |
5 | 31/M | 4 | Dorsum of hand and feet, forearm and shin | No | Summer exacerbation. Resolves completely in winter | Palmoplantar hyperhydrosis | 12 | Acitretin 25 mg* 8 weeks 10mg* 16 weeks. Topical 10% urea | Cleared completely. Seasonal recurrence. |