Table 2 Cognitive function, body composition and IGF-I SDS of PWS adolescents at different stages in the study

Total IQ

61

(55 to 69)

62

(58 to 69)

69

(60 to 73)

70

(57 to 80)

0.832

Verbal IQ

62

(55 to 66)

65

(57 to 70)

66

(57 to 75)

67

(55 to 76)

0.486

 - Vocabulary

−2.3

(−2.7 to −2.0)

−2.2

(−2.9 to −2.0)

−2.3

(−3.0 to −1.3)

−2.0

(−2.7 to −1.5)

0.650

 - Similarities

−1.8

(−2.2 to −1.7)

−1.7

(−2.3 to −1.1)

−1.3

(−2.3 to −1.0)

−1.3

(−2.3 to −1.0)

0.943

 - Arithmetic

−2.0

(−2.2 to −2.0)

−2.0

(−2.0 to −1.7)

−2.0

(−2.0 to −1.7)

−2.0

(−2.0 to −1.8)

0.320

 - Digit Span

−2.2

(−2.8 to −1.7)

−2.3

(−2.9 to −1.8)

−2.0

(−2.3 to −1.8)

−2.0

(−2.3 to −1.8)

0.793

 - Information

−1.7

(−2.6 to −1.7)

−1.8

(−2.0 to −1.4)

−1.7

(−2.0 to −1.1)

−1.8

(−2.3 to −1.3)

0.154

 - Comprehension

−2.3

(−2.7 to −2.3)

−2.2^a

(−2.6 to −2.0)

−2.0

(−2.6 to −1.4)

−2.0

(−2.6 to −1.4)

0.123

Performance IQ

59

(53 to 72)

57

(52 to 70)

67

(57 to 75)

69

(55 to 78)

0.322

 - Picture Completion

−2.2

(−2.9 to −1.7)

−2.5

(−2.9 to −1.7)

−1.7

(−2.8 to −0.8)

−1.3

(−2.3 to −0.4)

0.130

 - Coding

−3.0

(−3.0 to −2.2)

−2.7

(−3.0 to −2.3)

−2.5

(−3.0 to −1.5)

−2.3

(−3.0 to −1.5)

0.903

 - Block design

−2.0

(−2.2 to −1.4)

−1.5^a

(−2.0 to −1.3)

−1.7

(−1.8 to −1.2)

−1.7

(−2.0 to −1.0)

0.075

 - Matrix Reasoning

−1.7

(−2.1 to −1.3)

−2.3^a

(−2.3 to −1.7)

−2.2

(−2.3 to −1.2)

−2.2

(−2.3 to −1.3)

0.376

 - Picture Arrangement

−2.3

(−2.6 to −1.2)

−2.0

(−2.3 to −1.4)

−1.7

(−1.7 to −1.0)

−1.3

(−2.0 to −1.0)

0.611

FM%

45.3

(38.2 to 48.3)

41.7

(30.6 to 50.6)

39.3^a

(33.2 to 49.8)

44.1

(38.4 to 52.3)

0.002

Lean body mass (kg)

32.3

(30.6 to 45.1)

34.6^a

(31.6 to 44.0)

35.1

(32.6 to 41.3)

36.7

(31.5 to 39.2)

0.008

IGF-I SDS

−0.4

(−0.9 to −0.3)

2.1^a

(0.0 to 2.4)

1.8^a

(1.5 to 2.4)

−0.7

(−1.7 to 0.3)

<0.001