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Table 1 Baseline characteristics of total group and per treatment schedule

From: Effect of cessation of GH treatment on cognition during transition phase in Prader-Willi syndrome: results of a 2-year crossover GH trial

  PWS (n = 25) Placebo/GH (n = 12) GH / Placebo (n = 13) p*
Boys/girls (n)   7/18   3/9   4/9  
Genetic subtype        
- Deletion   9   2   7  
- mUPD   13   8   5  
- ICD/translocation   3   9   1  
Age (yrs) 17.8 (15.7 to 18.5) 17.2 (14.9 to 19.4) 17.8 (16.9 to 18.0) 0.852
Adult height (SDS) −1.7 (−2.2 to–1.0) −1.7 (−2.4 to–1.1) −1.8 (−2.0 to −0.9) 0.852
BMI for age (SDS) 1.1 (−0.8 to 1.7) 1.3 (−0.4 to 1.7) 1.1 (−0.8 to 2.0) 0.936
BMI for age PWS (SDS) −1.1 (−2.2 to −0.6) −1.2 (−2.2 to −0.6) −1.1 (−2.3 to −0.5) 0.689
Age at start GH treatment (yrs) 8.8 (6.3 to 10.1) 8.1 (5.8 to 9.8) 8.8 (6.9 to 11.2) 0.376
Duration of GH treatment (yrs) 8.6 (7.0 to 10.5) 8.7 (7.2 to 11.4) 8.3 (6.5 to 10.5) 0.650
IGF-I (SDS) 2.1 (1.7 to 3.0) 1.7 (1.1 to 3.0) 2.2 (2.0 to 3.0) 0.051
FM% 38.6 (32.3 to 44.9) 39.0 (32.4 to 45.6) 37.3 (30.5 to 44.9) 0.810
Lean body mass (kg) 36.5 (30.6 to 41.5) 35.0 (29.6 to 43.9) 37.0 (33.2 to 40.2) 0.611
Total IQ 62 (56 to 73) 60 (54 to 63) 67 (57 to 78) 0.095
Verbal IQ 65 (57 to 72) 66 (60 to 72) 65 (55 to 74) 0.713
- Vocabulary −2.3 (−2.8 to −1.7) −2.3 (−2.8 to −1.8) −2.0 (−2.8 to −1.4) 0.464
- Similarities −2.0 (−2.5 to −1.0) −2.0 (−2.7 to −1.5) −1.7 (−2.5 to −0.8) 0.382
- Arithmetic −2.0 (−2.0 to −1.7) −2.0 (−2.3 to −1.6) −2.0 (−2.0 to −1.6) 0.635
- Digit Span −2.0 (−2.3 to −2.0) −2.0 (−2.0 to −1.2) −2.3 (−2.4 to −1.9) 0.129
- Information −1.7 (−2.0 to −1.3) −1.7 (−1.8 to −1.3) −1.8 (−2.0 to −1.3) 0.792
- Comprehension −2.0 (−2.6 to −1.5) −2.2 (−2.7 to −1.6) −2.0 (−2.4 to −1.2) 0.792
Performance IQ 60 (54 to 72) 59 (54 to 67) 66 (52 to 74) 0.635
- Picture Completion −2.5 (−3.0 to −1.5) −2.5 (−2.8 to −1.7) −2.5 (−3.0 to −1.3) 0.792
- Coding −3.0 (−3.0 to −2.3) −3.0 (−3.0 to −2.6) −2.9 (−3.0 to −1.6) 0.428
- Block design −2.2 (−2.2 to −1.3) −2.0 (−3.0 to −1.5) −1.5 (−1.9 to −0.8) 0.034
- Matrix Reasoning −2.3 (−2.3 to −1.3) −2.0 (−2.3 to −1.7) −2.0 (−2.3 to −1.0) 0.786
- Picture Arrangement −2.7 (−2.7 to −1.5) −2.3 (−2.8 to −1.8) −1.7 (−2.0 to −1.4) 0.082
  1. Data expressed as median (IQR). *Comparison between two treatment schedules