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Table 1 Baseline characteristics of total group and per treatment schedule

From: Effect of cessation of GH treatment on cognition during transition phase in Prader-Willi syndrome: results of a 2-year crossover GH trial

 

PWS (n = 25)

Placebo/GH (n = 12)

GH / Placebo (n = 13)

p*

Boys/girls (n)

 

7/18

 

3/9

 

4/9

 

Genetic subtype

       

- Deletion

 

9

 

2

 

7

 

- mUPD

 

13

 

8

 

5

 

- ICD/translocation

 

3

 

9

 

1

 

Age (yrs)

17.8

(15.7 to 18.5)

17.2

(14.9 to 19.4)

17.8

(16.9 to 18.0)

0.852

Adult height (SDS)

−1.7

(−2.2 to–1.0)

−1.7

(−2.4 to–1.1)

−1.8

(−2.0 to −0.9)

0.852

BMI for age (SDS)

1.1

(−0.8 to 1.7)

1.3

(−0.4 to 1.7)

1.1

(−0.8 to 2.0)

0.936

BMI for age PWS (SDS)

−1.1

(−2.2 to −0.6)

−1.2

(−2.2 to −0.6)

−1.1

(−2.3 to −0.5)

0.689

Age at start GH treatment (yrs)

8.8

(6.3 to 10.1)

8.1

(5.8 to 9.8)

8.8

(6.9 to 11.2)

0.376

Duration of GH treatment (yrs)

8.6

(7.0 to 10.5)

8.7

(7.2 to 11.4)

8.3

(6.5 to 10.5)

0.650

IGF-I (SDS)

2.1

(1.7 to 3.0)

1.7

(1.1 to 3.0)

2.2

(2.0 to 3.0)

0.051

FM%

38.6

(32.3 to 44.9)

39.0

(32.4 to 45.6)

37.3

(30.5 to 44.9)

0.810

Lean body mass (kg)

36.5

(30.6 to 41.5)

35.0

(29.6 to 43.9)

37.0

(33.2 to 40.2)

0.611

Total IQ

62

(56 to 73)

60

(54 to 63)

67

(57 to 78)

0.095

Verbal IQ

65

(57 to 72)

66

(60 to 72)

65

(55 to 74)

0.713

- Vocabulary

−2.3

(−2.8 to −1.7)

−2.3

(−2.8 to −1.8)

−2.0

(−2.8 to −1.4)

0.464

- Similarities

−2.0

(−2.5 to −1.0)

−2.0

(−2.7 to −1.5)

−1.7

(−2.5 to −0.8)

0.382

- Arithmetic

−2.0

(−2.0 to −1.7)

−2.0

(−2.3 to −1.6)

−2.0

(−2.0 to −1.6)

0.635

- Digit Span

−2.0

(−2.3 to −2.0)

−2.0

(−2.0 to −1.2)

−2.3

(−2.4 to −1.9)

0.129

- Information

−1.7

(−2.0 to −1.3)

−1.7

(−1.8 to −1.3)

−1.8

(−2.0 to −1.3)

0.792

- Comprehension

−2.0

(−2.6 to −1.5)

−2.2

(−2.7 to −1.6)

−2.0

(−2.4 to −1.2)

0.792

Performance IQ

60

(54 to 72)

59

(54 to 67)

66

(52 to 74)

0.635

- Picture Completion

−2.5

(−3.0 to −1.5)

−2.5

(−2.8 to −1.7)

−2.5

(−3.0 to −1.3)

0.792

- Coding

−3.0

(−3.0 to −2.3)

−3.0

(−3.0 to −2.6)

−2.9

(−3.0 to −1.6)

0.428

- Block design

−2.2

(−2.2 to −1.3)

−2.0

(−3.0 to −1.5)

−1.5

(−1.9 to −0.8)

0.034

- Matrix Reasoning

−2.3

(−2.3 to −1.3)

−2.0

(−2.3 to −1.7)

−2.0

(−2.3 to −1.0)

0.786

- Picture Arrangement

−2.7

(−2.7 to −1.5)

−2.3

(−2.8 to −1.8)

−1.7

(−2.0 to −1.4)

0.082

  1. Data expressed as median (IQR). *Comparison between two treatment schedules