Patients Nr. | Seizures per months (median) | Duration of Everolimus Therapy (months) | Max. daily dose (mg/kg) | Median trough concentration (ng/ml) | Dosage (mg/m2) | ||||
---|---|---|---|---|---|---|---|---|---|
Baseline | 6 months | 12 months | 18 months | Last Observation | |||||
1* | 30 | 21 | 21 | 50 | 15 | 22 | 7.5 | 5.9 | 9.8 |
2 | 30 | 16 | 42.5 | - | 20 | 17 | 10 | 4.9 | 4.6 |
3* | 10 | 0 | 1 | 2 | 0 | 41 | 10 | 4.1 | 5.7 |
4* | 30 | 0 | 0 | 0 | 0 | 33 | 5 | 5.6 | 5.9 |
5* | 120 | 32.5 | 39.5 | 62.5 | 25 | 23 | 10 | 4.3 | 4.8 |
6* | 410 | 0 | 0 | 0 | 32 | 50 | 7.5 | 2 | 5.8 |
7* | 1 | 0 | - | - | 0 | 7 | 10 | 2.6 | 4.4 |
8 | 180 | 180 | - | - | 180 | 6 | 5 | 5.3 | 6 |
9* | 16 | 10 | 2.5 | 1 | 0 | 41 | 5 | 8.4 | 4.7 |
10* | 2 | 1.5 | 1 | 0 | 0 | 32 | 12.5 | 3.5 | 6.8 |
11* | 30 | 0.5 | - | - | 0 | 14 | 4 | 1.5 | 2.6 |
12 | 90 | 90 | - | - | 50 | 10 | 10 | 3.2 | 8.4 |
13* | 30 | 0.5 | 0.5 | 0 | 0 | 21 | 5 | 4.2 | 4.6 |
14* | 149 | 211 | 62.5 | 46 | 63 | 23 | 4 | 7.7 | 7.2 |
15* | 90 | 21.5 | 2 | 1.5 | 1 | 20 | 7.5 | 4.7 | 8.6 |