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Table 2 Summary of the β-catenin and NICD immunofluorescent analyses in SIOD and isolated FSGS patient kidney tissue

From: Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?

Patient ID Unphosphorylated β-catenin expression Nuclear NICD expression
SIOD patients
 SD4b = =
 SD26
 SD60
 SD60 Tx = =
 SD79 =
 SD120
 SD121
 SD131 n/aa
 SD146
Isolated FSGS patients
 FSGS-1 =
 FSGS-2
 FSGS-3
 FSGS-4
 FSGS-5
 FSGS-6
 FSGS-8
 FSGS-9
 FSGS-10
  1. Abbreviation: = staining comparable to unaffected control kidney, increased staining compared to unaffected control kidney, FSGS focal segmental glomerulosclerosis, ID identification, n/a not available, NICD Notch1 intracellular domain, SIOD Schimke immuno-osseous dysplasia, Tx transplant
  2. aNo more tissue sections were available for analysis