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Table 2 Summary of the β-catenin and NICD immunofluorescent analyses in SIOD and isolated FSGS patient kidney tissue

From: Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?

Patient ID

Unphosphorylated β-catenin expression

Nuclear NICD expression

SIOD patients

 SD4b

=

=

 SD26

↑

↑

 SD60

↑

↑

 SD60 Tx

=

=

 SD79

↑

=

 SD120

↑

↑

 SD121

↑

↑

 SD131

n/aa

↑

 SD146

↑

↑

Isolated FSGS patients

 FSGS-1

↑

=

 FSGS-2

↑

↑

 FSGS-3

↑

↑

 FSGS-4

↑

↑

 FSGS-5

↑

↑

 FSGS-6

↑

↑

 FSGS-8

↑

↑

 FSGS-9

↑

↑

 FSGS-10

↑

↑

  1. Abbreviation: = staining comparable to unaffected control kidney, ↑ increased staining compared to unaffected control kidney, FSGS focal segmental glomerulosclerosis, ID identification, n/a not available, NICD Notch1 intracellular domain, SIOD Schimke immuno-osseous dysplasia, Tx transplant
  2. aNo more tissue sections were available for analysis