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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?

Fig. 2

Immunofluorescent detection of unphosphorylated β-catenin in the glomerular cells of SIOD patient and unaffected control kidneys. Immunostaining with anti-unphosphorylated β-catenin (Alexa Fluor 594) in unaffected control kidney (a) and SIOD patient kidneys (b-h). The nuclei were counterstained with 4', 6-diamidino-2-phenylindole (DAPI). The boxed regions correspond to the higher magnification images on the right. The glomeruli have been outlined to aid in the visualization of β-catenin expression. Scale bars: overview images (200×) and higher magnification images (400×) = 100 microns. Abbreviations: DAPI, 4', 6-diamidino-2-phenylindole

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