Fig. 1
From: Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?
Genome-wide and targeted gene expression analyses in an SIOD patient kidney. a Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of upregulated genes (log2 fold change > 1) in an SIOD kidney compared to a sex-matched unaffected control kidney. A Bonferroni-corrected p value of < 0.05 was used as a threshold for determining significant KEGG pathways. The horizontal axis represents the -log10 (p value) of significant KEGG pathways. The number of unique DAVID gene IDs involved in a given term is indicated within the bar representing each pathway. b and c Volcano plots comparing the expression of Wnt (b) and Notch (c) pathway genes and targets in an SIOD patient kidney to an unaffected control kidney. White, grey, and black dots respectively represent downregulated (log2 fold change < −1), unchanged, and upregulated (log2 fold change > 1) expression in the SIOD kidney versus the unaffected control kidney. For genes above the dotted line, the differential expression has a p value of less than 0.05. Abbreviations: ECM, extracellular matrix; SIOD, Schimke immuno-osseous dysplasia