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Table 2 Expression levels of miRNAs that showed significant difference between TSC and control groups. P-levels are calculated for a comparison of the whole TSC group with controls. Results for all miRNAs evaluated by the serum panels used for the profiling experiment are presented in Additional file 2: Table S2

From: Abnormal serum microRNA profiles in tuberous sclerosis are normalized during treatment with everolimus: possible clinical implications

 

TSC2 (N = 5)

TSC1 (N = 4)

No mutation (N = 1)

All patients with TSC (N = 10)

Controls (N = 10)

Expression ratio TSC/Control

P value

Benjamini-Hochberg FDR

miR-142-5p

−1.71 ± 0.26

−1.35 ± 0.53

−2.49

−1.65 ± 0.49

−0.52 ± 0.34

0.46

0.0000

0.0010

miR-199a-5p

−2.93 ± 0.56

−2.84 ± 0.34

Undetected

−2.89 ± 0.47

−1.06 ± 0.73

0.28

0.0000

0.0010

miR-142-3p

0.84 ± 0.50

0.73 ± 0.23

1.06

0.82 ± 0.38

1.78 ± 0.57

0.52

0.0003

0.0146

miR-136-5p

−3.88 ± 0.85

−4.29 ± 0.51

−3.44

−3.98 ± 0.69

−2.35 ± 0.77

0.32

0.0005

0.0156

miR-130a-3p

−0.71 ± 0.33

−0.57 ± 0.18

−1.88

−0.77 ± 0.46

−1.70 ± 0.53

1.90

0.0006

0.0156

miR-378a-3p

−0.57 ± 0.33

−0.87 ± 0.40

0.35

−0.60 ± 0.48

−1.79 ± 0.75

2.28

0.0007

0.0157

miR-130b-3p

−4.16 ± 0.48

−4.16 ± 0.22

Undetected

−4.16 ± 0.38

−4.84 ± 0.32

1.60

0.0017

0.0287

miR-192-5p

−2.18 ± 0.55

−2.21 ± 0.86

−2.19

−2.20 ± 0.62

−3.14 ± 0.38

1.92

0.0017

0.0287

miR-25-3p

1.25 ± 0.56

1.09 ± 0.16

0.79

1.14 ± 0.41

0.44 ± 0.49

1.63

0.0027

0.0389

miR-215-5p

−3.18 ± 0.74

−3.58 ± 0.57

−3.51

−3.35 ± 0.63

−4.50 ± 0.64

2.21

0.0029

0.0389

miR-222-3p

−0.43 ± 0.44

−0.09 ± 0.30

0.92

−0.16 ± 0.56

−1.27 ± 0.74

2.16

0.0031

0.0389