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Table 1 Patient demographics and baseline disease characteristicsa

From: Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: pooled analysis of two trials

 

Erivance BCC (N = 104)

EAS (N = 119)

 

laBCC

mBCC

laBCC

mBCC

 

BCCNS

(n = 22)

Non-BCCNS

(n = 49)

Non-BCCNS

(n = 33)

BCCNS

(n = 12)

Non-BCCNS

(n = 50)

BCCNS

(n = 7)

Non-BCCNS

(n = 50)

Median age, years (range)

47 (21–71)

67 (38–101)

62 (38–92)

52 (26–79)

67 (40–92)

58 (37–71)

63 (24–100)

Female, n (%)

10 (45)

22 (45)

9 (27)

6 (50)

13 (26)

3 (43)

9 (18)

WCBP, n (%)

3 (33)

1 (2)

2 (6)

4 (33)

2 (4)

1 (14)

1 (2)

ECOG PS, n (%)

 0–1

22 (100)

44 (90)

32 (97)

12 (100)

46 (92)

7 (100)

45 (90)

 2

0

5 (10)

1 (3)

0

4 (8)

0

5 (10)

Target lesions, n (%)

 1

13 (59)

35 (71)

9 (27)

4 (33)

30 (60)

4 (57)

20 (40)

 2

4 (18)

8 (16)

4 (12)

2 (17)

11 (22)

0

10 (20)

 ≥3

5 (23)

6 (12)

20 (61)

6 (50)

9 (18)

3 (43)

20 (40)

Prior treatment, n (%)

 Surgery

21 (96)

41 (84)

32 (97)

12 (100)

45 (90)

7 (100)

47 (94)

 Radiotherapy

1 (5)

21 (43)

19 (58)

1 (8)

19 (38)

2 (29)

33 (66)

 Systemic therapy

5 (23)

3 (6)

10 (30)

2 (17)

9 (18)

2 (29)

18 (36)

Surgery contraindicated, n (%)

18 (82)

25 (51)

NA

7 (58)

28 (56)

NA

NA

  1. BCCNS basal cell carcinoma nevus syndrome, EAS expanded access study, ECOG PS Eastern Cooperative Oncology Group performance status, laBCC locally advanced basal cell carcinoma, mBCC metastatic basal cell carcinoma, NA not available, WCBP women of childbearing potential
  2. aThere were no patients with BCCNS with mBCC in the ERIVANCE BCC study; therefore, this column is omitted in the table