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Table 4 Comparison of HRQoL according to the EQ-5D utility value in MPS IVA (Morquio A) patients with different levels of mobility impairment and other serious chronic diseases

From: Health-related quality of life in mucopolysaccharidosis: looking beyond biomedical issues

Disease HRQoL mean utilitya
MPS IVA: adults, no wheelchair [28] 0.846
MPS IVA: adults, sometimes wheelchair [28] 0.582
MPS IVA: adults, always wheelchair [28] 0.057
Multiple sclerosis, walking-aid [75] 0.460
Multiple sclerosis, bedridden [75] −0.195
Moderate to severe rheumatoid arthritis [76] 0.489
Chronic ischaemic heart disease [77] 0.640
Non-insulin dependent diabetes mellitus [77] 0.670
  1. aEQ-5D utility scores were calculated using a time tradeoff method [78]. This generates scores ranging from −0.59 to 1, where 1 means full health and zero stands for death. Negative scores could be emotively interpreted as a health state “worse than death”. Tradeoff tariffs used differed depending on the ethnic background of patients