Establishment of reference values of α-tocopherol in plasma, red blood cells and adipose tissue in healthy children to improve the management of chylomicron retention disease, a rare genetic hypocholesterolemia

Table 2 Age-partitioned pediatric reference intervals for vitamin E in plasma, red blood cells (RBC) and adipose tissue

Test	Age (years)	Samples (n)	Mean	Lower limit	Upper limit
Plasma α-tocopherol (μmol/L)	0 - 2	48	22.1	11.8	34.2
	2 - 12	73	20	11.9	30.2
	12 - 18	35	19.8	11.6	27.6
	0 - 18	156	20.6	11.9	30
α-tocopherol/cholesterol ratio	0 - 18	113	5.27	3.3	7.1
α-tocopherol/triglycerides ratio	0 - 18	113	33.3	9.6	55.3
RBC α-tocopherol (μmol/L packed cells)	0 - 2	30	5.47	2.5	9.9
	2 - 12	37	4.67	1.7	7.8
	12 - 18	28	5.12	2.6	9.8
	0 - 18	95	4.96	2	7.8
Adipose tissue α-tocopherol (nmol/g)	0 - 2	48	291	37	597
	2 - 12	64	267	61	596
	12 - 18	32	177	58	344
	0 - 18	144	258	60	573

ISSN: 1750-1172