Diffuse reduction of cerebral grey matter volumes in Erdheim-Chester disease

Diamond, Eli L.; Hatzoglou, Vaios; Patel, Sneha; Abdel-Wahab, Omar; Rampal, Raajit; Hyman, David M.; Holodny, Andrei I.; Raj, Ashish

doi:10.1186/s13023-016-0490-3

Orphanet Journal of Rare Diseases

Table 2 Comparison of cortical thickness and subcortical volumes between ECD Patients and age-matched controls

From: Diffuse reduction of cerebral grey matter volumes in Erdheim-Chester disease

A. Left Hemisphere							B. Right Hemisphere
Cluster	Location	Size (mm2)	logP	TalX	TalY	TalZ	Cluster	Location	Size (mm2)	logP	TalX	TalY	TalZ
1	Superior parietal	1052	−7.81	−19	−65	59	1	Precentral	3832	−7.06	42	−6	55
2	Supramarginal	3359	−7.62	−59	−51	21	2	Postcentral	601	−6.42	44	−28	62
3	Postcentral	602	−7.35	−42	−29	63	3	Entorhinal	1662	−6.00	21	−10	−30
4	Precentral	1942	−6.64	−29	−16	67	4	Superior frontal	3856	−5.62	9	20	60
5	Superior frontal	1986	−6.39	−7	50	40	5	Precentral	107	4.96	19	−31	55
6	Inferior parietal	539	−6.06	−35	−77	38	6	Superior temporal	884	−4.83	66	−32	10
7	Caudal middle frontal	915	−5.66	−35	16	51	7	Supramarginal	443	−4.81	57	−33	45
8	Fusiform	313	−5.26	−30	−40	−22	8	Lateral occipital	920	−4.68	43	−83	−12
9	Inferior parietal	417	5.20	−32	−74	20	9	Inferior parietal	870	−4.67	46	−60	45
10	Precentral	277	−5.13	−58	6	25	10	Superior parietal	280	−4.15	34	−49	63
11	Precuneus	216	−4.25	−7	−55	16	11	Superior parietal	660	−4.07	21	−78	44
12	Entorhinal	207	−4.13	−20	−10	−31	12	Fusiform	316	−3.71	29	−57	−15
13	Posterior cingulate	261	−3.61	−6	−29	38	13	Inferior parietal	266	3.17	33	−70	23
14	Pericalcarine	489	3.58	−9	−82	12	14	Precuneus	79	3.16	12	−54	33
15	Lateral occipital	375	−3.51	−16	−100	5	15	Pars opercularis	464	−3.03	55	22	16
16	Supramarginal	195	−3.42	−61	−31	36	16	Posterior cingulate	158	−3.02	6	−19	40
17	Inferior temporal	113	−3.28	−46	−12	−39
18	Lateral occipital	98	−3.24	−43	−82	0
19	Lateral occipital	101	−3.04	−34	−87	10
20	Precentral	122	−3.01	−57	2	7
21	Pars orbitalis	68	−3.01	−46	36	−14
C. Subcortical Volumes
Volume				Group		Mean volume (cm3)		STD		95 % CI		p-value
Subcortical gray matter (all)				ECD		57		5.1		5.4–6.1		<0.0001
Subcortical gray matter (all)				Control		158		21.6		145.7–170.6
White matter (right hemisphere)				ECD		247		42.3		218.8–275.7		0.75
White matter (right hemisphere)				Control		237		388		214.0–258.9
White matter (left hemisphere)				ECD		246		43.5		216.3–274.7		0.74
White matter (left hemisphere)				Control		238		39.7		214.3–260.2
Cerebellar grey matter (right)				ECD		50		6.9		45.0–54.2		0.6
Cerebellar grey matter (right)				Control		43		8.1		38.1–47.5
Cerebellar grey matter (left)				ECD		48		7.4		42.8–52.7		0.97
Cerebellar grey matter (left)				Control		43		7.5		38.9–47.6

Significant clusters with FDR corrected p <0.001 are listed in order of descending statistical significance with anatomic location, cluster size in mm², log(10)P, and Talairach coordinates for the cortical regions of the left (A) and right (B) hemispheres. Comparison of subcortical volumes, including total white matter, total grey matter, and total cerebellar volumes, is presented in (C)

Back to article page

ISSN: 1750-1172

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com