From: Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases
Reference (s) | Age (yr)/sex | EB subtype | Site of cSCC | Histological differentiation/size of tumor (cm) | Site(s) of metastases | Treatment | Outcome |
---|---|---|---|---|---|---|---|
Schwartz16 | 55 F | DDEB | Lower extremity (knee) | Well/>5 | Not applicable | Intra arterial Doxorubicin + MTX |
Surgical excision Survival unknown |
Lentz17 |
22 F 26 F | RDEB |
Upper extremity (forearm) Trunk |
Well/unknown Unknown/>2 < 5 |
Axillary lymph nodes, pulmonary nodules Axillary lymph nodes |
Cisplatin 5FU-cisplatin |
PR Death from cSCC PR, surgical resection, alive at 12mo |
Arnold7 | 24 F | RDEB | Upper (elbow) and lower (feet) extremities | Well/>5 | Axillary lymph nodes |
1.5FU-cisplatin 2. carboplatin-taxol 3. cetuximab |
1. PR 2. PD 3. GR, alive at 3mo |
Kim18 |
26 F 43 M | RDEB |
Upper (hand) extremity Unknown |
Moderately/>5 Well/>5 |
Axillary lymph nodes, pulmonary nodules Axillary lymph nodes, pulmonary nodules |
1. cetuximab 2. cetuximab-gemcitabine 1. cetuximab 2. MTX orally 3. MTX IV |
1. PD 2. Death from pneumonia 1. PD 2. Death from pneumonia |