From: Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases
Reference (s) | Age (yr)/sex | EB subtype | Site of cSCC | Histological differentiation/size of tumor (cm) | Site(s) of metastases | Treatment | Outcome |
---|---|---|---|---|---|---|---|
Schwartz16 | 55 F | DDEB | Lower extremity (knee) | Well/>5 | Not applicable | Intra arterial Doxorubicin + MTX | Surgical excision Survival unknown |
Lentz17 | 22 F 26 F | RDEB | Upper extremity (forearm) Trunk | Well/unknown Unknown/>2 < 5 | Axillary lymph nodes, pulmonary nodules Axillary lymph nodes | Cisplatin 5FU-cisplatin | PR Death from cSCC PR, surgical resection, alive at 12mo |
Arnold7 | 24 F | RDEB | Upper (elbow) and lower (feet) extremities | Well/>5 | Axillary lymph nodes | 1.5FU-cisplatin 2. carboplatin-taxol 3. cetuximab | 1. PR 2. PD 3. GR, alive at 3mo |
Kim18 | 26 F 43 M | RDEB | Upper (hand) extremity Unknown | Moderately/>5 Well/>5 | Axillary lymph nodes, pulmonary nodules Axillary lymph nodes, pulmonary nodules | 1. cetuximab 2. cetuximab-gemcitabine 1. cetuximab 2. MTX orally 3. MTX IV | 1. PD 2. Death from pneumonia 1. PD 2. Death from pneumonia |