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Table 3 Skeletal muscle properties of patients with mitochondrial myopathy (n = 6) and healthy controls (n = 8)

From: Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy

 

Patients

Controls

P-value

Type I fibers (%)

34.8 ± 3.6

55.7 ± 5.9

< 0.001

Type II fibers (%)

65.2 ± 3.6

44.3 ± 5.9

< 0.001

CSA total (μm2)

3,438 ± 915

4,698 ± 1,328

0.070

CSA type I fibers (μm2)

3991 ± 1211

5234 ± 1566

0.133

CSA type II fibers (μm2)

3,178 ± 852

4,359 ± 1,592

0.127

MitoVD (%)

4.0 ± 0.5

5.1 ± 0.8

< 0.05

IMFVD (%)

3.4 ± 0.4

4.1 ± 0.5

< 0.05

SSVD (%)

0.6 ± 0.3

1.0 ± 0.5

0.118

LDVD (%)

0.4 ± 0.1

0.4 ± 0.3

0.660

  1. Values are represented as means ± SD. CSA cross sectional area; IMF VD intermyofibrilar mitochondrial volume density, LD VD lipid droplet volume density, Mito VD mitochondrial volume density, SS VD subsarcolemmal mitochondrial volume density