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Table 1 Physiological characteristics of patients with mitochondrial myopathy (n = 6) and healthy controls (n = 8)

From: Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy

 

Patients

Controls

P-value

Age (yr)

53 ± 9

58 ± 14

0.437

Body mass (kg)

75 ± 18

67 ± 12

0.376

Height (cm)

162 ± 7

167 ± 7

0.238

BMC (kg)

2.3 ± 0.18

2.4 ± 0.4

0.867

Fat mass (kg)

23.1 ± 16.3

14.2 ± 11.6

0.255

Lean mass (kg)

38.4 ± 13.3

41.4 ± 13.9

0.683

Lean mass legs (kg)

19.3 ± 11.1

19.0 ± 8.8

0.951

Total body fat (%)

39 ± 13

31 ± 6

0.153

Relative V̇O2peak (mL min−1 kg−1)

19.8 ± 6.8a

32.6 ± 7.3

<0.01

P peak (W)

78 ± 21a

165 ± 60

< 0.05

[L−]rest (mmol L−1)

1.64 ± 0.88

1.11 ± 0.62

0.207

RER25W (-)

0.72 ± 0.06a

0.69 ± 0.06

0.447

RERrel (-)

0.78 ± 0.08a

0.77 ± 0.05

0.923

HRpeak(min−1)

144 ± 28a

158 ± 16

0.257

tlim (s)

278 ± 154a

541 ± 321

0.118

MVC (Nm)

54.3 ± 41.9a

80.6 ± 43.3b

0.278

  1. Values are represented as means ± SD. BMC bone mineral content; [L−], blood lactate concentration at rest; HR peak peak heart rate, MVC maximum voluntary contraction, P peak peak power; relative V̇O2peak, peak oxygen uptake per kg body weight; RER 25W respiratory exchange ratio at 25 W, RER rel respiratory exchange ratio at 50 % P peak, t lim time to exhaustion. a n = 5; b n = 7