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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Multicenter Female Fabry Study (MFFS) - clinical survey on current treatment of females with Fabry disease

Fig. 2

Differences between patients with and without ERT at least one organ manifestation justifying ERT according to current guidelines. a Distribution of manifestations in different organs justifying ERT with class I (ERT is recommended) and class IIA/B (ERT should/may be considered) recommendations. b Accumulation of different organ manifestations justifying ERT. Females may present with one to five different manifestations (green, yellow, orange, red, black represent 1, 2, 3, 4, 5 simultaneous manifestations, respectively). Cardiac: presence of left ventricular hypertrophy; Renal: eGFR <90 ml/min/1.73 m2; CNS: stroke/ transient ischemic attack; Pain: neuropathic/FD-related pain; GI: gastrointestinal symptoms (diarrhea, abdominal pain)

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