Table 1 Detailed patient characteristics
From: Neurocognitive outcome in tyrosinemia type 1 patients compared to healthy controls
Time of diagnosis (months) | Patient | Age at diagnosis (months) | Current age (years) | Duration of NTBC treatment (years) | Clinical problems at diagnosis |
|---|---|---|---|---|---|
≤2 | 1 | 0,3 | 9,2 | 9,1 | pre-symptomatically |
2 | 0,03 | 14,0 | 14,0 | ||
3 | 0,03 | 15,3 | 15,3 | ||
4 | 0,2 | 8,1 | 8,0 | ||
5 | 0,03 | 15,6 | 15,6 | ||
6 | 0,1 | 12,1 | 12,1 | ||
7 | 0,1 | 10,3 | 10,3 | ||
8 | 0,5 | 10,4 | 10,4 | ||
9 | 0,1 | 8,8 | 8,8 | ||
10 | 1,7 | 10,4 | 10,2 | ||
2–6 | 11 | 3,2 | 7,9 | 7,6 | Acute liver failure and renal tubulopathy |
12 | 4,1 | 13,4 | 13,1 | Acute liver failure | |
13 | 2,9 | 9,7 | 9,5 | Acute liver failure | |
14 | 3,8 | 9,9 | 9,6 | Acute liver failure | |
15 | 3,0 | 16,0 | 15,8 | Acute liver failure, renal tubulopathy and rickets | |
16 | 5,0 | 17,7 | 17,3 | Renal tubulopathy, nefromegaly and rickets | |
≥6 | 17 | 8,6 | 23,4 | 20,6 | Liver cirrhosis |
18 | 13,0 | 7,9 | 6,7 | Liver cirrhosis | |
19 | 38,7 | 23,6 | 20,4 | Liver cirrhosis, renal tubulopathy and rickets |