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Table 4 Variation in clinical attributes with family history of HAM/TSP (n = 383)

From: Nation-wide epidemiological study of Japanese patients with rare viral myelopathy using novel registration system (HAM-net)

Attribute   Familial HAM/TSP
(n = 32, 8.4 %)
Non-Familial HAM/TSP
(n = 351, 91.6 %)
p Value
Sex: Female 19 (59.4 %) 265 (75.5 %) .046
  Male 13 (40.6 %) 86 (24.5 %)
History of ATLLa: Yes 5 (15.6 %) 17 (4.8 %) .012
History of Blood Transfusion: Yes (anytime) 2 (6.3 %) 71 (20.4 %) .052
Yes, before 1986 2 (6.3 %) 55 (15.8 %) .147
Age at Onset   32.5 (25 – 45) 46 (34 – 56) .000
Age at Diagnosis   40 (30 – 54) 55 (44 – 62) .000
Age (at Presentb)   58 (52 – 66) 64 (56 – 70) .018
Diagnosis Delay (Time from Onset to Diagnosis) 6 (2 – 12) 5 (1 – 12) .765
Disease Duration (Time from Onset to Presentb) 23.5 (14 – 32) 16 (8 – 25) .002
OMDS (Range: 0 – 13)   5.0 (5.0 – 8.0) 5.0 (5.0 – 7.0) .481
HAQ-DI (Range: 0 – 3)   0.9 (0.5 – 1.9) 1.1 (0.8 – 1.6) .677
  1. Data are summarized using the number of subjects (percentage of total subjects) or the median (interquartile range). The full names of the scales and surveys shown are Osame Motor Disability Score (OMDS) and Health Assessment Questionnaire – Disability Index (HAQ-DI). The values for time-points are given in years, and scale and survey results are reported as scores. n values vary between n = 379 and n = 383 due to incomplete data
  2. aHistory of ATLL indicates the subject has a first- or second-degree relative with adult T-cell leukemia/lymphoma (ATLL)
  3. bPresent is defined as the time of the subject’s initial HAM-net interview