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Table 4 Variation in clinical attributes with family history of HAM/TSP (n = 383)

From: Nation-wide epidemiological study of Japanese patients with rare viral myelopathy using novel registration system (HAM-net)

Attribute

 

Familial HAM/TSP

(n = 32, 8.4 %)

Non-Familial HAM/TSP

(n = 351, 91.6 %)

p Value

Sex:

Female

19

(59.4 %)

265

(75.5 %)

.046

 

Male

13

(40.6 %)

86

(24.5 %)

History of ATLLa:

Yes

5

(15.6 %)

17

(4.8 %)

.012

History of Blood Transfusion:

Yes (anytime)

2

(6.3 %)

71

(20.4 %)

.052

Yes, before 1986

2

(6.3 %)

55

(15.8 %)

.147

Age at Onset

 

32.5

(25 – 45)

46

(34 – 56)

.000

Age at Diagnosis

 

40

(30 – 54)

55

(44 – 62)

.000

Age (at Presentb)

 

58

(52 – 66)

64

(56 – 70)

.018

Diagnosis Delay (Time from Onset to Diagnosis)

6

(2 – 12)

5

(1 – 12)

.765

Disease Duration (Time from Onset to Presentb)

23.5

(14 – 32)

16

(8 – 25)

.002

OMDS (Range: 0 – 13)

 

5.0

(5.0 – 8.0)

5.0

(5.0 – 7.0)

.481

HAQ-DI (Range: 0 – 3)

 

0.9

(0.5 – 1.9)

1.1

(0.8 – 1.6)

.677

  1. Data are summarized using the number of subjects (percentage of total subjects) or the median (interquartile range). The full names of the scales and surveys shown are Osame Motor Disability Score (OMDS) and Health Assessment Questionnaire – Disability Index (HAQ-DI). The values for time-points are given in years, and scale and survey results are reported as scores. n values vary between n = 379 and n = 383 due to incomplete data
  2. aHistory of ATLL indicates the subject has a first- or second-degree relative with adult T-cell leukemia/lymphoma (ATLL)
  3. bPresent is defined as the time of the subject’s initial HAM-net interview
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172