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Table 1 2007–2013 Canadian Orphan Drug Landscape and Expenditure (2014 CAD, Millions)

From: Pharmaceutical expenditure on drugs for rare diseases in Canada: a historical (2007–13) and prospective (2014–18) MIDAS sales data analysis

Measure 2007 2008 2009 2010 2011 2012 2013
# “Orphan only” drugs captured N = 108 70 74 73 79 81 91 99
# “Partial Orphan” drugs captured N = 39 25 26 27 28 30 31 34
# Total Orphan drugs captured N = 147 95 100 100 107 111 122 133
“Orphan Only” Drug Expenditure ($M) 537.6 586.7 649.2 692.6 729.3 786.8 868.0
“Partial Orphan” Drug Expenditure ($M) 72.6 82.5 94.5 125.5 151.2 202.8 232.0
Total Orphan Drug Expenditure ($M) 610.2 669.2 743.7 818.1 880.5 989.6 1,100.0
% “Orphan Only”/Total Orphan Expenditure 88.1 % 87.7 % 87.3 % 84.7 % 82.8 % 79.5 % 78.9 %
% “Partial Orphan”/Total Orphan Expenditure 11.9 % 12.3 % 12.7 % 15.3 % 17.2 % 20.5 % 21.1 %
Total Pharmaceutical Expenditure ($M) 18,233.6 19,598.1 20,514.4 20,628.6 19,976.3 19,746.0 19,665.7
% Total Orphan/Total Pharmaceutical Expenditure 3.3 % 3.4 % 3.6 % 4.0 % 4.4 % 5.0 % 5.6 %