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Table 1 2007–2013 Canadian Orphan Drug Landscape and Expenditure (2014 CAD, Millions)

From: Pharmaceutical expenditure on drugs for rare diseases in Canada: a historical (2007–13) and prospective (2014–18) MIDAS sales data analysis

Measure

2007

2008

2009

2010

2011

2012

2013

# “Orphan only” drugs captured N = 108

70

74

73

79

81

91

99

# “Partial Orphan” drugs captured N = 39

25

26

27

28

30

31

34

# Total Orphan drugs captured N = 147

95

100

100

107

111

122

133

“Orphan Only” Drug Expenditure ($M)

537.6

586.7

649.2

692.6

729.3

786.8

868.0

“Partial Orphan” Drug Expenditure ($M)

72.6

82.5

94.5

125.5

151.2

202.8

232.0

Total Orphan Drug Expenditure ($M)

610.2

669.2

743.7

818.1

880.5

989.6

1,100.0

% “Orphan Only”/Total Orphan Expenditure

88.1 %

87.7 %

87.3 %

84.7 %

82.8 %

79.5 %

78.9 %

% “Partial Orphan”/Total Orphan Expenditure

11.9 %

12.3 %

12.7 %

15.3 %

17.2 %

20.5 %

21.1 %

Total Pharmaceutical Expenditure ($M)

18,233.6

19,598.1

20,514.4

20,628.6

19,976.3

19,746.0

19,665.7

% Total Orphan/Total Pharmaceutical Expenditure

3.3 %

3.4 %

3.6 %

4.0 %

4.4 %

5.0 %

5.6 %