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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Slow, progressive myopathy in neonatally treated patients with infantile-onset Pompe disease: a muscle magnetic resonance imaging study

Fig. 2

Muscle MRI in neonatally treated infants and toddlers with IOPD. a T1WIs (left panel) and T2WIs (right panel) of thigh muscle MRI scans obtained at 1 year of age from NBS10 (upper panel) and an age- and sex-matched control (lower panel) were compared. NBS10 presented hyperintensity at the bilateral quadriceps, particularly the vastus intermedius, on T2WIs (asterisk) but not on T1WIs. In addition, increased fat in the intramuscular fascia (between the vastus lateralis and rectus femoris) was also observed (arrow). b T1WIs (left panel) and T2WIs (right panel) of thigh muscle MRI scans obtained at 3 years of age from NBS10 (upper panel) and an age- and sex-matched control (middle panel) were compared. NBS10 presented hyperintensity at the bilateral vastus intermedius and less hyperintensity at the vastus lateralis on T2WIs (asterisk) but not on T1WIs, showing a significant decrease compared with previous images obtained at 1 year of age. In addition, hyperintensity at the bilateral rectus femoris (triangles) was clearly evident on both T1WIs and T2WIs. Increased fat in the intramuscular fascia (between the vastus lateralis and rectus femoris) was also observed but had not progress (arrow)

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172