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Table 2 Expression of genes near the chromosome 14 and 18 breakpoints

From: Complex translocation disrupting TCF4 and altering TCF4 isoform expression segregates as mild autosomal dominant intellectual disability

Chromosome 18

Gene

Chromosome

UDP4637 FPKM

Control FPKM

log (UDP/Control)

p-value

q-value

Significant

MBD2

chr18

10.0

9.0

−0.15

0.250

0.39

no

SNORA37

chr18

0.0

0.0

0.00

1.000

1.00

no

POLI

chr18

3.7

2.7

−0.47

0.001

0.00

yes a

STARD6

chr18

0.0

0.0

0.00

1.000

1.00

no

C18orf54

chr18

3.0

1.4

−1.09

0.000

0.00

yes a

DYNAP

chr18

2.6

0.0

N/A

0.000

0.00

yes a

RAB27B

chr18

0.6

1.7

1.52

0.000

0.00

yes a

CCDC68

chr18

0.3

1.1

2.02

0.000

0.00

yes a

TCF4

chr18

17.6

21.5

0.29

0.026

0.06

no

LOC100505474

chr18

0.0

0.0

0.00

1.000

1.00

no

TXNL1

chr18

22.5

25.7

0.19

0.155

0.27

no

WDR7

chr18

6.7

6.4

−0.08

0.563

0.70

no

BOD1P

chr18

0.0

0.0

inf

1.000

1.00

no

Chromosome 14

Gene

Chromosome

UDP4637 FPKM

Control FPKM

log (UDP/Control)

p-value

q-value

Significant

TEX21P

chr14

0.1

0.1

−0.04

1.00

1.00

no

MTHFD1

chr14

32.0

29.4

−0.12

0.36

0.51

no

AKAP5

chr14

0.1

0.5

2.15

0.00

0.00

yes a

ZBTB25

chr14

2.4

2.5

0.08

0.66

0.78

no

ZBTB1

chr14

13.2

14.6

0.15

0.28

0.42

no

HSPA2

chr14

53.3

120.4

1.18

0.00

0.00

yes

PPP1R36

chr14

0.3

0.3

0.16

0.71

0.81

no

PLEKHG3

chr14

2.5

3.2

0.35

0.02

0.05

yes a

SPTB

chr14

0.0

0.1

0.74

1.00

1.00

no

CHURC1,CHURC1-FNTB,FNTB

chr14

20.3

20.4

0.01

0.97

0.98

no

GPX2

chr14

0.0

0.0

inf

1.00

1.00

no

LOC100506321

chr14

0.0

0.1

1.83

1.00

1.00

no

MAX

chr14

23.2

18.8

−0.31

0.26

0.40

no

MIR4706

chr14

0.0

0.0

0.00

1.00

1.00

no

RAB15

chr14

3.4

2.3

−0.54

0.23

0.37

no

  1. a FPKM value too low to interpret as significant (as evaluated by cufflinks)