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Table 7 Prophylaxis with danazol and comparison of location-related symptoms between women and men in 2012

From: Hereditary angioedema due to C1 - inhibitor deficiency in Switzerland: clinical characteristics and therapeutic modalities within a cohort study

Location of attacks

All

Women

no prophylaxis vs. Danazol

Men

no prophylaxis vs. Danazol

women vs. men

All

No prophylaxis

Danazol

p-values

All

No prophylaxis

Danazol

p-values

p-values

 

104

57

31

13

 

47

28

13

  

abdomen

68 (65 %)

40 (70 %)

24 (77 %)

6 (46 %)

p = 0.042

28 (59 %)

15 (53 %)

9 (69 %)

p = 0.344

p = 0.063

extremities

61 (59 %)

34 (60 %)

20 (64 %)

5 (38 %)

p = 0.111

27 (57 %)

14 (50 %)

8 (61 %)

p = 0.491

p = 0.157

trunk

22 (21 %)

15 (26 %)

8 (26 %)

3 (10 %)

p = 0.849*

7 (15 %)

4 (14 %)

0

p = 0.288*

p = 0.523*

face

22 (21 %)

14 (24 %)

8 (26 %)

2 (6 %)

p = 0.697*

8 (17 %)

4 (14 %)

1 (8 %)

p = 0.486**

p = 0.709**

genitals

22 (21 %)

11 (19 %)

8 (26 %)

1 (3 %)

p = 0.242*

11 (23 %)

5 (18 %)

3 (23 %)

p = 0.692*

p = 0.586*

headache

16 (15 %)

11 (19 %)

4 (13 %)

3 (10 %)

p = 0.404*

5 (11 %)

4 (14 %)

0

p = 0.288*

p = 0.509*

larynx

16 (15 %)

9 (16 %)

6 (19 %)

1 (3 %)

p = 0.654

7 (15 %)

4 (14 %)

1 (8 %)

p = 0.486**

p = 0.700**

  1. * Fisher’s exact test, ** one-sided
  2. Number of patients who suffered from at least one attack in the individual location in 2012