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Table 6 Multivariate logistic regression analysis of respiratory problems by gender and mutation type

From: Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome

  Any autonomic dysfunction Breath-holding Hyperventilation Respiratory problemab Pneumonia everb
  (n = 41) (n = 33) (n = 17) (n = 28) (n = 27)
  n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value
  N = 115    N = 114    N = 117    N = 111    N = 115   
Age group                
 0 to <5 years 47 (40.9) baseline 46 (40.4) baseline 49 (41.9) baseline 44(39.6) 47 (40.9)
 5 to 10 years 39 (33.9) 1.83 (0.68,4.95) 0.24 40 (35.1) 2.15 (0.74,6.19) 0.16 38 (32.5) 1.92 (0.49,7.59) 0.35 37(33.3) 37 (32.2)
 10 years or older 29 (25.2) 2.18 (0.76,6.25) 0.15 28 (24.6) 1.72 (0.54,5.45) 0.36 30 (25.6) 2.58 (0.61,10.83) 0.20 30(27.0) 31 (27.0)
Gender                
 Female 102 (88.7) baseline 101 (88.6) baseline 104 (88.9) baseline 97 (87.4) baseline 101 (87.8) baseline
 Male 13 (11.3) 3.65 (1.02,13.04) 0.05 13 (11.4) 4.71 (1.30,16.99) 0.02 13 (11.1) 0.70 (0.08,6.23) 0.75 14 (12.6) 5.84 (1.67,20.47) 0.01 14 (12.2) 7.51 (2.16,26.09) 0.002
Mutation group                
 No functional protein 41 (35.7) baseline 41 (36.0) baseline 44 (37.6) baseline 40 (36.0) baseline 42 (36.5) baseline
 Missense/in-frame mutation within catalytic domain 35 (30.4) 1.94 (0.69,5.48) 0.21 33 (29.0) 1.56 (0.52,4.68) 0.43 34 (29.1) 3.02 (0.67,13.65) 0.15 33 (29.7) 1.17 (0.34,3.99) 0.80 33 (28.7) 0.77 (0.21,2.84) 0.70
 Truncation between aa172 and aa781 30 (26.1) 1.12 (0.36,3.46) 0.85 30 (26.3) 0.85 (0.25,2.88) 0.80 30 (25.6) 2.69 (0.55,13.03) 0.22 26 (23.4) 1.13 (0.30,4.30) 0.86 28 (24.4) 1.42 (0.40,5.03) 0.58
 Truncation after aa781 9 (7.8) 0.30 (0.03,2.76) 0.30 10 (8.8) 0.29 (0.03,2.72) 0.28 9 (7.7) 1.52 (0.13,17.50) 0.74 12 (10.8) 0.65 (0.11,3.84) 0.63 12 (10.4) 1.18 (0.23,6.08) 0.85
  1. OR odds ratio - the relative odds of having the outcome in the category of interest compared to the odds of having the outcome in the baseline category; CI confidence interval
  2. aRespiratory problems that required hospital admission or doctor consultation
  3. bPrevalence of respiratory problems and pneumonia were not analysed by age group as the question asked about past history not current occurrence