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Table 6 Multivariate logistic regression analysis of respiratory problems by gender and mutation type

From: Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome

 

Any autonomic dysfunction

Breath-holding

Hyperventilation

Respiratory problemab

Pneumonia everb

 

(n = 41)

(n = 33)

(n = 17)

(n = 28)

(n = 27)

 

n (%)

OR (95 % CI)

p value

n (%)

OR (95 % CI)

p value

n (%)

OR (95 % CI)

p value

n (%)

OR (95 % CI)

p value

n (%)

OR (95 % CI)

p value

 

N = 115

  

N = 114

  

N = 117

  

N = 111

  

N = 115

  

Age group

               

 0 to <5 years

47 (40.9)

baseline

–

46 (40.4)

baseline

–

49 (41.9)

baseline

–

44(39.6)

–

–

47 (40.9)

–

–

 5 to 10 years

39 (33.9)

1.83 (0.68,4.95)

0.24

40 (35.1)

2.15 (0.74,6.19)

0.16

38 (32.5)

1.92 (0.49,7.59)

0.35

37(33.3)

–

–

37 (32.2)

–

–

 10 years or older

29 (25.2)

2.18 (0.76,6.25)

0.15

28 (24.6)

1.72 (0.54,5.45)

0.36

30 (25.6)

2.58 (0.61,10.83)

0.20

30(27.0)

–

–

31 (27.0)

–

–

Gender

               

 Female

102 (88.7)

baseline

–

101 (88.6)

baseline

–

104 (88.9)

baseline

–

97 (87.4)

baseline

–

101 (87.8)

baseline

–

 Male

13 (11.3)

3.65 (1.02,13.04)

0.05

13 (11.4)

4.71 (1.30,16.99)

0.02

13 (11.1)

0.70 (0.08,6.23)

0.75

14 (12.6)

5.84 (1.67,20.47)

0.01

14 (12.2)

7.51 (2.16,26.09)

0.002

Mutation group

               

 No functional protein

41 (35.7)

baseline

–

41 (36.0)

baseline

–

44 (37.6)

baseline

–

40 (36.0)

baseline

–

42 (36.5)

baseline

–

 Missense/in-frame mutation within catalytic domain

35 (30.4)

1.94 (0.69,5.48)

0.21

33 (29.0)

1.56 (0.52,4.68)

0.43

34 (29.1)

3.02 (0.67,13.65)

0.15

33 (29.7)

1.17 (0.34,3.99)

0.80

33 (28.7)

0.77 (0.21,2.84)

0.70

 Truncation between aa172 and aa781

30 (26.1)

1.12 (0.36,3.46)

0.85

30 (26.3)

0.85 (0.25,2.88)

0.80

30 (25.6)

2.69 (0.55,13.03)

0.22

26 (23.4)

1.13 (0.30,4.30)

0.86

28 (24.4)

1.42 (0.40,5.03)

0.58

 Truncation after aa781

9 (7.8)

0.30 (0.03,2.76)

0.30

10 (8.8)

0.29 (0.03,2.72)

0.28

9 (7.7)

1.52 (0.13,17.50)

0.74

12 (10.8)

0.65 (0.11,3.84)

0.63

12 (10.4)

1.18 (0.23,6.08)

0.85

  1. OR odds ratio - the relative odds of having the outcome in the category of interest compared to the odds of having the outcome in the baseline category; CI confidence interval
  2. aRespiratory problems that required hospital admission or doctor consultation
  3. bPrevalence of respiratory problems and pneumonia were not analysed by age group as the question asked about past history not current occurrence