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Table 4 Multinomial logistic analysis of frequency of coughing by age group, gender and mutation group

From: Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome

  Do not occur Sometimes occur Often occur
  (n = 25) (n = 47) (n = 21)
  n (%) n (%) RRR (95 % CI) p value n (%) RRR (95 % CI) p value
Age group        
 0 to <5 years 7 (28.0) 24 (54.6) 13 (61.9)
 5 to <10 years 10 (40.0) 13 (46.4) 0.26 (0.07,1.01) 0.05 5 (23.8) 0.13 (0.02,0.73) 0.02
 10 years or older 8 (32.0) 11 (22.9) 0.25 (0.06,0.98) 0.05 3 (14.3) 0.16 (0.03,0.91) 0.04
Gender        
 Female 23 (92.0) 44 (91.7) 19 (90.5)  
 Male 2 (8.0) 4 (8.3) 1.83 (0.17,20.20) 0.62 2 (9.5) 0.80 (0.04,16.47) 0.88
Mutation group        
 No functional protein 8 (32.0) 15 (31.9)
 Missense/in-frame mutation within catalytic domain 6 (24.0) 12 (25.5) 1.05 (0.26,4.32) 0.94 6 (28.6) 1.32 (0.25,7.13) 0.74
 Truncation between aa172 and aa781 6 (24.0) 12 (25.5) 1.30 (0.31,5.48) 0.72 4 (19.1) 1.10 (0.18,6.67) 0.92
 Truncation after aa781 2 (8.0) 5 (10.6) 1.23 (0.19,8.05) 0.83 3 (14.3) 2.36 (0.26,21.16) 0.44
  1. RRR relative risk ratio; CI confidence interval
  2. Frequency of coughing grouped as the following: - do not occur (never); sometimes (less than 1/week and 1–2 times per week); often occur (daily and more than 1/day)